Nonoparticles of biodegradable polymers for new-concept chemotherapy

被引：150

作者：

Feng, SS

机构：

[1] Natl Univ Singapore, Fac Engn, Dept Environm Chem & Engn, Singapore 119260, Singapore

[2] Natl Univ Singapore, Fac Engn, Dept Bioengn, Singapore 119260, Singapore

来源：

EXPERT REVIEW OF MEDICAL DEVICES | 2004年 / 1卷 / 01期

关键词：

anticancer drugs; biomaterials; blood-brain barrier; cancer; chemothetapeutic engineering; controlled release; drug delivery; oral chemotherapy; paclitaxel; targeted delivery;

D O I：

10.1586/17434440.1.1.115

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

The current regimen of chemotherapy is for from satisfactory - its efficiency is limited and patients suffer from serious side effects. Various drug delivery devices have been under Intensive Investigation In the past few decades In attempts to develop controlled and targeted methods of chemotherapy administration. This article reviews the latest developments In nanoparticles of biodegradable polymers for chemotherapy of cancer and other diseases such as cardiovascular restenosis. The preliminary results obtained in the author's laboratory are used to demonstrate the concept. This review is written with the belief that engineering, in particular, chemical engineering principles, can be applied and further developed to solve the problems in the current practice of chemotherapy and promote a new concept of chemotherapy - chemotherapy at home.

引用

页码：115 / 125

页数：11

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