The influence of aminotransferase levels on liver stiffness assessed by Acoustic Radiation Force Impulse Elastography: A retrospective multicentre study

被引：59

作者：

Bota, Simona ^{[1
]}

Sporea, Ioan ^{[1
]}

Peck-Radosavljevic, Markus ^{[2
]}

Sirli, Roxana ^{[1
]}

Tanaka, Hironori ^{[3
]}

Iijima, Hiroko ^{[3
]}

Saito, Hidetsugu ^{[4
]}

Ebinuma, Hirotoshi ^{[4
]}

Lupsor, Monica ^{[5
]}

Badea, Radu ^{[5
]}

Fierbinteanu-Braticevici, Carmen ^{[6
]}

Petrisor, Ana ^{[6
]}

Friedrich-Rust, Mireen ^{[7
]}

Sarrazin, Christoph ^{[7
]}

Takahashi, Hirokazu ^{[8
]}

Ono, Naofumi ^{[9
]}

Piscaglia, Fabio ^{[10
]}

Marinelli, Sara ^{[10
]}

D'Onofrio, Mirko ^{[11
]}

Gallotti, Anna ^{[11
]}

Salzl, Petra ^{[2
]}

Popescu, Alina ^{[1
]}

Danila, Mirela ^{[1
]}

机构：

[1] Victor Babes Univ Med & Pharm, Dept Gastroenterol & Hepatol, Timisoara, Romania

[2] Med Univ Vienna, Div Gastroenterol & Hepatol, Vienna, Austria

[3] Hyogo Coll Med, Dept Internal Med, Nishinomiya, Hyogo 6638501, Japan

[4] Keio Univ, Sch Med, Dept Internal Med, Tokyo, Japan

[5] Univ Med, Med Clin 3, Cluj Napoca, Romania

[6] Univ Hosp, Med Clin & Gastroenterol 2, Bucharest, Romania

[7] JW Goethe Univ Hosp, Dept Internal Med 1, Frankfurt, Germany

[8] Saga Med Sch, Dept Internal Med, Saga, Japan

[9] Eguchi Hosp, Dept Gastroenterol, Saga, Japan

[10] Univ & Gen Hosp S Orsola Malpighi, Div Internal Med, Dept Clin Med, Bologna, Italy

[11] Univ Verona, Dept Radiol, Univ Hosp GB Rossi, I-37100 Verona, Italy

来源：

DIGESTIVE AND LIVER DISEASE | 2013年 / 45卷 / 09期

关键词：

Acoustic Radiation Force Impulse (ARFI); Elastography; Aminotransferase levels; Liver fibrosis; Liver stiffness; Transient Elastography; CHRONIC HEPATITIS-C; UNIDIMENSIONAL TRANSIENT ELASTOGRAPHY; CHRONIC VIRAL-HEPATITIS; REAL-TIME ELASTOGRAPHY; NONINVASIVE ASSESSMENT; FIBROSIS EVALUATION; ARFI ELASTOGRAPHY; BIOPSY; PERFORMANCE; CIRRHOSIS;

D O I：

10.1016/j.dld.2013.02.008

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Background: Acoustic Radiation Force Impulse Elastography is a new method for non-invasive evaluation of liver fibrosis. Aim: To evaluate the impact of elevated alanine aminotransferase levels on liver stiffness assessment by Acoustic Radiation Force Impulse Elastography. Methods: A multicentre retrospective study including 1242 patients with chronic liver disease, who underwent liver biopsy and Acoustic Radiation Force Impulse. Transient Elastography was also performed in 512 patients. Results: The best Acoustic Radiation Force Impulse cut-off for predicting significant fibrosis was 1.29 m/s in cases with normal alanine aminotransferase levels and 1.44 m/s in patients with alanine aminotransferase levels > 5x the upper limit of normal. The best cut-off for predicting liver cirrhosis were 1.59 and 1.75 m/s, respectively. Acoustic Radiation Force Impulse cut-off for predicting significant fibrosis and cirrhosis were relatively similar in patients with normal alanine aminotransferase and in those with alanine aminotransferase levels between 1.1 and 5x the upper limit of normal: 1.29 m/s vs. 1.36 m/s and 1.59 m/s vs. 1.57 m/s, respectively. For predicting cirrhosis, the Transient Elastography cut-offs were significantly higher in patients with alanine aminotransferase levels between 1.1 and 5x the upper limit of normal compared to those with normal alanine aminotransferase: 12.3 kPa vs. 9.1 kPa. Conclusion: Liver stiffness values assessed by Acoustic Radiation Force Impulse and Transient Elastography are influenced by high aminotransferase levels. Transient Elastography was also influenced by moderately elevated aminotransferase levels. (C) 2013 Editrice Gastroenterologica Italiana S.r.l. Published by Elsevier Ltd. All rights reserved.

引用

页码：762 / 768

页数：7

共 40 条

[1] NONINVASIVE IN VIVO LIVER FIBROSIS EVALUATION USING SUPERSONIC SHEAR IMAGING: A CLINICAL STUDY ON 113 HEPATITIS C VIRUS PATIENTS [J].

Bavu, Eric ;

Gennisson, Jean-Luc ;

Couade, Mathieu ;

Bercoff, Jeremy ;

Mallet, Vincent ;

Fink, Mathias ;

Badel, Anne ;

Vallet-Pichard, Anais ;

Nalpas, Bertrand ;

Tanter, Mickael ;

Pol, Stanislas .

ULTRASOUND IN MEDICINE AND BIOLOGY, 2011, 37 (09) :1361-1373

[2]

BEDOSSA P, 1994, HEPATOLOGY, V20, P15

[3] Fibrosis staging in chronic hepatitis C: analysis of discordance between transient elastography and liver biopsy [J].

Calvaruso, V. ;

Camma, C. ;

Di Marco, V. ;

Maimone, S. ;

Bronte, F. ;

Enea, M. ;

Dardanoni, V. ;

Manousou, P. ;

Pleguezuelo, M. ;

Xirouchakis, E. ;

Attanasio, M. ;

Dusheiko, G. ;

Burroughs, A. K. ;

Craxi, A. .

JOURNAL OF VIRAL HEPATITIS, 2010, 17 (07) :469-474

[4] Direct comparison of diagnostic performance of transient elastography in patients with chronic hepatitis B and chronic hepatitis C [J].

Cardoso, Ana-Carolina ;

Carvalho-Filho, Roberto J. ;

Stern, Christiane ;

Dipumpo, Alexandrine ;

Giuily, Nathalie ;

Ripault, Marie-Pierre ;

Asselah, Tarik ;

Boyer, Nathalie ;

Lada, Olivier ;

Castelnau, Corinne ;

Martinot-Peignoux, Michelle ;

Valla, Dominique-Charles ;

Bedossa, Pierre ;

Marcellin, Patrick .

LIVER INTERNATIONAL, 2012, 32 (04) :612-621

[5] Prospective comparison of transient elastography, fibrotest, APRI, and liver biopsy for the assessment of fibrosis in chronic hepatitis C [J].

Castéra, L ;

Vergniol, J ;

Foucher, J ;

Le Bail, B ;

Chanteloup, E ;

Haaser, M ;

Darriet, M ;

Couzigou, P ;

De Lédinghen, V .

GASTROENTEROLOGY, 2005, 128 (02) :343-350

[6] Alanine aminotransferase-based algorithms of liver stiffness measurement by transient elastography (Fibroscan) for liver fibrosis in chronic hepatitis B [J].

Chan, H. L. -Y. ;

Wong, G. L. -H. ;

Choi, P. C. -L. ;

Chan, A. W. -H. ;

Chim, A. M. -L. ;

Yiu, K. K. -L. ;

Chan, F. K. -L. ;

Sung, J. J. -Y. ;

Wong, V. W. -S. .

JOURNAL OF VIRAL HEPATITIS, 2009, 16 (01) :36-44

[7] Transient elastography: a new surrogate marker of liver fibrosis influenced by major changes of transaminases [J].

Coco, B. ;

Oliveri, F. ;

Maina, A. M. ;

Ciccorossi, P. ;

Sacco, R. ;

Colombatto, P. ;

Bonino, F. ;

Brunetto, M. R. .

JOURNAL OF VIRAL HEPATITIS, 2007, 14 (05) :360-369

[8] Evaluation of liver fibrosis by transient elastography using acoustic radiation force impulse: comparison with Fibroscan® [J].

Ebinuma, Hirotoshi ;

Saito, Hidetsugu ;

Komuta, Mina ;

Ojiro, Keisuke ;

Wakabayashi, Kanji ;

Usui, Shingo ;

Chu, Po-sung ;

Umeda, Rumiko ;

Ishibashi, Yuka ;

Takayama, Tetsurou ;

Kikuchi, Masahiro ;

Nakamoto, Nobuhiro ;

Yamagishi, Yoshiyuki ;

Kanai, Takanori ;

Ohkuma, Kiyoshi ;

Sakamoto, Michiie ;

Hibi, Toshifumi .

JOURNAL OF GASTROENTEROLOGY, 2011, 46 (10) :1238-1248

[9] Acoustic radiation force imaging sonoelastography for noninvasive staging of liver fibrosis [J].

Fierbinteanu-Braticevici, Carmen ;

Andronescu, Dan ;

Usvat, Radu ;

Cretoiu, Dragos ;

Baicus, Cristian ;

Marinoschi, Gabriela .

WORLD JOURNAL OF GASTROENTEROLOGY, 2009, 15 (44) :5525-5532

[10] Controversies in liver biopsy: Who, where, when, how, why? [J].

Friedman L.S. .

Current Gastroenterology Reports, 2004, 6 (1) :30-36

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