Nitric oxide inhibitory activity of monogalactosylmonoacylglycerols from a freshwater microalgae Chlorella sorokiniana

被引：28

作者：

Banskota, Arjun H. ^{[1
]}

Stefanova, Roumiana ^{[1
]}

Gallant, Pamela ^{[1
]}

Osborne, Jane A. ^{[1
]}

Melanson, Ronald ^{[1
]}

O'Leary, Stephen J. B. ^{[1
]}

机构：

[1] Natl Res Council Canada, Inst Marine Biosci, Halifax, NS B3H 3Z1, Canada

来源：

NATURAL PRODUCT RESEARCH | 2013年 / 27卷 / 11期

关键词：

monogalactosylmonoacylglycerol; nitric oxide; Chlorella sorokiniana; microalgae;

D O I：

10.1080/14786419.2012.696255

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

Chemical investigation of the freshwater microalgae Chlorella sorokiniana led to the isolation of a new monogalactosylmonoacylglycerol, namely, (2S)-1-O-(7Z,10Z-hexadecadienoyl)-3-O--D-galactopyranosylglycerol (1) together with a known glycolipid (2S)-1-O-(7Z,10Z,13Z-hexadecatrienoyl)-3-O--D-galactopyranosylglycerol (2). Both monogalactosylmonoacylglycerols showed dose-dependent nitric oxide (NO) inhibitory activity against lipopolysaccharide-induced NO production in RAW264.7 macrophage cells suggesting their possible use as anti-inflammatory agents.

引用

页码：1028 / 1031

页数：4

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