Apoptosis-inducing galactolipids from a cultured, marine diatom, Phaeodactylum tricornutum

被引：49

作者：

Andrianasolo, Eric H. ^{[1
]}

Haramaty, Liti ^{[1
]}

Vardi, Assaf ^{[1
]}

White, Eileen ^{[2
,3
,4
]}

Lutz, Richard ^{[1
]}

Falkowski, Paul ^{[1
]}

机构：

[1] Rutgers State Univ, Inst Marine & Coastal Sci, Ctr Marine Biotechnol, New Brunswick, NJ 08901 USA

[2] Rutgers State Univ, Dept Mol Biol & Biochem, Ctr Adv Biotechnol & Med, Piscataway, NJ 08854 USA

[3] Univ Med & Dent New Jersey, Robert Wood Johnson Med Sch, Piscataway, NJ 08854 USA

[4] Canc Inst New Jersey, New Brunswick, NJ 08903 USA

来源：

JOURNAL OF NATURAL PRODUCTS | 2008年 / 71卷 / 07期

关键词：

D O I：

10.1021/np800124k

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Two monogalactosyl diacylglycerols, 1 and 2, were isolated from the marine diatom Phaeodactylum tricornutum, using the patented ApopScreen cell-based screen for apoptosis-inducing, potential anticancer compounds. The molecular structures of the galactolipids were determined using a combination of NMR, mass spectrometry, and chemical degradation. The bioactivities were confirmed using a specific apoptosis induction assay based on genetically engineered mammalian cell lines with differential, defined capacities for apoptosis. The galactolipids induce apoptosis in micromolar concentrations. This is the first report of apoptosis induction by galactolipids.

引用

页码：1197 / 1201

页数：5

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