Mitochondrial AAA-type protease Yme1p is involved in Bax effects on cytochrome c oxidase

被引：19

作者：

Manon, S ^{[1
]}

Priault, M ^{[1
]}

Camougrand, N ^{[1
]}

机构：

[1] Univ Bordeaux 2, CNRS, UMR5095, F-33077 Bordeaux, France

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 2001年 / 289卷 / 05期

关键词：

D O I：

10.1006/bbrc.2001.6120

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Expression of the pro-apoptotic protein Bax in yeast Saccharomyces cerevisiae induces a release of cytochrome c accompanied by a decrease of the amount of cytochrome c oxidase. Here we show that the decrease of cytochrome c oxidase is due to the activation of mitochondrial protease Yme1p, of which cytochrome c oxidase subunit 2 (Cox2p) is a substrate. The absence of Yme1p slightly delays Bax-induced cell death, suggesting a role of this protease in yeast cell death and thus of its mammalian homologue in apoptosis. (C) 2001 Elsevier Science.

引用

页码：1314 / 1319

页数：6

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