Cytotoxic dammarane glycosides from processed ginseng

被引：51

作者：

Park, IH ^{[1
]}

Piao, LZ ^{[1
]}

Kwon, SW ^{[1
]}

Lee, YJ ^{[1
]}

Cho, SY ^{[1
]}

Park, MK ^{[1
]}

Park, JH ^{[1
]}

机构：

[1] Seoul Natl Univ, Coll Pharm, Seoul 151742, South Korea

来源：

CHEMICAL & PHARMACEUTICAL BULLETIN | 2002年 / 50卷 / 04期

关键词：

Panax ginseng; cytotoxicity; ginsenoside;

D O I：

10.1248/cpb.50.538

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Steaming ginseng at high temperature increased its cytotoxicity to SK-Hep-1 hepatoma cancer cells. HPLC separation and fractionation followed by MTT assay revealed that ginsenosides Rg(3), Rg(5), Rk(1), Rs(5), and Rs(4) are the active principles. Their 50% growth inhibition concentration (GI(50)) values were 41, 11, 13, 37, and 13 muM, respectively. Cisplatin had a GI(50) of 84 muM in the same assay conditions.

引用

页码：538 / 540

页数：3

共 7 条

[1]

HAILIN W, 1999, J CHROMATOGR B, V731, P403

[2] Antioxidant and anti-tumor promoting activities of the methanol extract of heat-processed ginseng [J].