Regulation of plasminogen activator inhibitor type 1 gene expression by inflammatory mediators and statins

被引：90

作者：

Kruithof, Egbert K. O. ^{[1
]}

机构：

[1] Univ Hosp Geneva, Div Angiol & Hemostasis, CH-1211 Geneva, Switzerland

来源：

THROMBOSIS AND HAEMOSTASIS | 2008年 / 100卷 / 06期

关键词：

Plasminogen activator inhibitor type 1; gene regulation; inflammation; statins;

D O I：

10.1160/TH08-04-0269

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Elevated plasma concentrations of plasminogen activator inhibitor type 1 (PAI-1), also named serpin E1, are encountered in patients with thrombophilia, atherosclerosis, septicemia and the metabolic syndrome and may be associated with an increased risk of complications. Expression of PAI-1 is increased by inflammatory stimuli and decreased by statins, drugs widely used in patients with cardiovascular disease. Increased expression of PAI-1 by inflammatory stimuli is mediated by a large variety of signal transduction pathways, which include the NF-kappa B and MAP kinase pathways. The downregulating effect of statins on PAI-1 expression is dependent on the inhibition of Rho family proteins and may involve an activation of PI-3 kinase/Akt signaling pathways. In this review we summarize the findings on the effect of inflammation and statins on PAI-1 expression.

引用

页码：969 / 975

页数：7

共 76 条

[1] PAI-1 and the metabolic syndrome - Links, causes, and consequences [J].

Alessi, Marie-Christine ;

Juhan-Vague, Irene .

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 2006, 26 (10) :2200-2207

[2] Protective effects of statin involving both eNOS and tPA in focal cerebral ischemia [J].

Asahi, M ;

Huang, ZH ;

Thomas, S ;

Yoshimura, S ;

Sumii, T ;

Mori, T ;

Qiu, JH ;

Amin-Hanjani, S ;

Huang, PL ;

Liao, JK ;

Lo, EH ;

Moskowitz, MA .

JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM, 2005, 25 (06) :722-729

[3] Targeting plasminogen activator inhibitor-1: Role in cell signaling and the biology of domain-specific knock-in mice [J].

Balsara, R. D. ;

Xui, Z. ;

Ploplis, V. A. .

CURRENT DRUG TARGETS, 2007, 8 (09) :982-995

[4] HMG CoA reductase inhibitors reduce plasminogen activator inhibitor-1 expression by human vascular smooth muscle and endothelial cells [J].

Bourcier, T ;

Libby, P .

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 2000, 20 (02) :556-562

[5] G-protein-coupled receptor activation induces the membrane translocation and activation of phosphatidylinositol-4-phosphate 5-kinase Iα by a Rac- and Rho-dependent pathway [J].

Chatah, NEH ;

Abrams, CS .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2001, 276 (36) :34059-34065

[6] Sp1 sites mediate activation of the plasminogen activator inhibitor-1 promoter by glucose in vascular smooth muscle cells [J].

Chen, YQ ;

Su, M ;

Walia, RR ;

Hao, Q ;

Covington, JW ;

Vaughan, DE .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1998, 273 (14) :8225-8231

[7] Differential mechanisms of plasminogen activator inhibitor-1 gene activation by transforming growth factor-β and tumor necrosis factor-α in endothelial cells [J].

Chen, YQ ;

Sloan-Lancaster, J ;

Berg, DT ;

Richardson, MA ;

Grinnell, B ;

Tseng-Crank, J .

THROMBOSIS AND HAEMOSTASIS, 2001, 86 (06) :1563-1572

[8]

Colicelli John, 2004, Sci STKE, V2004, pRE13, DOI 10.1126/stke.2502004re13

[9] Plasminogen activation and cancer [J].

Dano, K ;

Behrendt, N ;

Hoyer-Hansen, G ;

Johnsen, M ;

Lund, LR ;

Ploug, M ;

Romer, J .

THROMBOSIS AND HAEMOSTASIS, 2005, 93 (04) :676-681

[10]

DAWSON SJ, 1993, J BIOL CHEM, V268, P10739

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