Antifungal alkyl amino alcohols from the tropical marine sponge Haliclona n. sp.

被引：57

作者：

Clark, RJ

Garson, MJ ^{[1
]}

Hooper, JNA

机构：

[1] Univ Queensland, Dept Chem, Brisbane, Qld 4072, Australia

[2] Queensland Museum, Brisbane, Qld 4101, Australia

来源：

JOURNAL OF NATURAL PRODUCTS | 2001年 / 64卷 / 12期

关键词：

D O I：

10.1021/np010246x

中图分类号：

Q94 [植物学];

学科分类号：

071001 [植物学];

摘要：

Three new amino alcohols presumably deriving from L-alanine were isolated from the tropical marine sponge Haliclona n. sp. and characterized by 2D NMR, while a fourth amino alcohol was characterized as an acetamide derivative. Relative stereochemistry was deduced from the NMR characteristics of oxazolidinone derivatives and absolute stereochemistry secured by preparation and analysis of an MPA ester. The amino alcohol fraction from Haliclona n. sp, acts as an antifungal agent and inhibits the development of larvae of the ascidian Herdmania curvata.

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页码：1568 / 1571

页数：4

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