The transcriptome of Plasmodium vivax reveals divergence and diversity of transcriptional regulation in malaria parasites

被引：206

作者：

Bozdech, Zbynek ^{[1
]}

Mok, Sachel ^{[1
]}

Hu, Guangan ^{[1
]}

Imwong, Mallika ^{[2
]}

Jaidee, Anchalee ^{[3
]}

Russell, Bruce ^{[4
]}

Ginsburg, Hagai ^{[5
]}

Nosten, Francois ^{[3
]}

Day, Nicholas P. J. ^{[2
]}

White, Nicholas J. ^{[2
]}

Carlton, Jane M. ^{[6
]}

Preiser, Peter R. ^{[1
]}

机构：

[1] Nanyang Technol Univ, Sch Biol Sci, Singapore 637551, Singapore

[2] Wellcome Trust Mahidol Univ, Oxford Trop Med Res Programme, Salaya 73170, Nakhon Pathom, Thailand

[3] Mahidol Univ, Fac Trop Med Res, Shoklo Malaria Res Unit, Salaya 73170, Nakhon Pathom, Thailand

[4] Agcy Sci Technol & Res, Singapore Immunol Network, Lab Malaria Immunobiol, Singapore 138632, Singapore

[5] Hebrew Univ Jerusalem, Inst Life Sci, Dept Biol Chem, IL-91904 Jerusalem, Israel

[6] NYU, Langone Med Ctr, Dept Med Parasitol, New York, NY 10010 USA

来源：

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 2008年 / 105卷 / 42期

基金：

英国医学研究理事会;

关键词：

comparative genomics; Plasmodium falciparum;

D O I：

10.1073/pnas.0807404105

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Plasmodium vivax causes over 100 million clinical infections each year. Primarily because of the lack of a suitable culture system, our understanding of the biology of this parasite lags significantly behind that of the more deadly species P. falciparum. Here, we present the complete transcriptional profile throughout the 48-h intraerythrocytic cycle of three distinct A vivax isolates. This approach identifies strain specific patterns of expression for subsets of genes predicted to encode proteins associated with virulence and host pathogen interactions. Comparison to A falciparum revealed significant differences in the expression of genes involved in crucial cellular functions that underpin the biological differences between the two parasite species. These data provide insights into the biology of P. vivax and constitute an important resource for the development of therapeutic approaches.

引用

页码：16290 / 16295

页数：6

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