Purpose The aim of this study was to analyse the clinical and radiographic results of 208 e-Motion (R) posterior cruciate-retaining, mobile bearing prostheses (BBraun-Aesculap, Tuttlingen, Germany) fitted using computer navigation, for knee osteoarthritis with a genu varum greater than 10 degrees. Methods One hundred ninety-two patients were operated on with 208 e-Motion (R) prostheses fitted, between January 2006 and December 2011, using the OrthoPilot (R) computer navigation system. Average pre-operative IKS score was 70 +/- 27 points (6-143) with a function score of 38 +/- 20.5 (0-90) and a knee score of 32.5 +/- 13 (0-63). Average flexion was 116.5 degrees +/- 13 degrees (65-140 degrees). Average pre-operative HKA angle was 166 degrees +/- 3 degrees (154-169 degrees). Results 2Results are available for 134 patients, with a total of 150 knees operated on (38 lost to follow-up and 20 deceased). Average follow-up was 104.5 months (60-116 months). On last follow-up, the average IKS was 180 +/- 22 points (95-200) with 86.5 +/- 16 points (25-100) for the function score and 93.5 +/- 8 points (55-100) for the knee score. Knee flexion was 116 degrees +/- 10.5 degrees (80-135 degrees) and average HKA angle was 179 degrees +/- 2 degrees (175-184 degrees). The pre-operative objective was achieved in 90.5% of knees. Conclusion The e-Motion (R) mobile bearing posterior cruciate-retaining prosthesis, fitted using computer navigation, offers excellent results after an average of 8.5 years follow-up. These results are at least equivalent, even superior, to those of the posterior-stabilised prostheses usually used for this type of deformity.