Phospholipase D, tumor promoters, proliferation and prostaglandins

被引：27

作者：

Daniel, LW ^{[1
]}

Sciorra, VA

Ghosh, S

机构：

[1] Wake Forest Univ, Sch Med, Dept Biochem, Winston Salem, NC 27157 USA

[2] Glaxo Wellcome Inc, Res Triangle Pk, NC 27709 USA

来源：

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS | 1999年 / 1439卷 / 02期

关键词：

phospholipase D; tumor promoter; prostaglandin H synthase type 2; Raf-1;

D O I：

10.1016/S1388-1981(99)00099-2

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Phosphatidylcholine hydrolysis by phospholipase D is a widespread response to cellular stimulation. However, the downstream signaling events subsequent to phosphatidylcholine hydrolysis are just beginning to be determined. Initially it was proposed that diglyceride formation by phospholipase D and phosphatidate phosphohydrolase resulted in long-term stimulation of protein kinase C. However, recent studies indicate that phosphatidic acid is the relevant signaling molecule in some signaling pathways. The present review will summarize studies of phospholipase D in the response of cells to the tumor promoter 12-O-tetradecanoyl-phorbol-13-acetate, which causes cells to mimic the phenotype of oncogenic transformation. The role of phospholipase D in stimulation of Raf-1 and prostaglandin H synthase type-2 is emphasized. (C) 1999 Elsevier Science B.V. All rights reserved.

引用

页码：265 / 276

页数：12

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