Microwave assisted, highly efficient solid state N- and S-alkylation

被引：12

作者：

Jaisinghani, HG ^{[1
]}

Khadilkar, BM ^{[1
]}

机构：

[1] Univ Bombay, Dept Chem Technol, Bombay 400019, Maharashtra, India

来源：

SYNTHETIC COMMUNICATIONS | 1999年 / 29卷 / 21期

关键词：

D O I：

10.1080/00397919908086007

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Secondary amines and thiophenols were alkylated with alkyl and benzyl halides rapidly on alumina supported potassium carbonate under solvent-free conditions using microwaves. Equimolar amounts of the secondary amine/thiophenol and alkyl halide were used. The procedure neither required any strong base nor a PTC. Aniline was also monobenzylated with benzylchloride. Separation of the products from the reactants was very simple by using a nonpolar solvent for desorption.

引用

页码：3693 / 3698

页数：6

共 32 条

[21]

ONO N, 1980, SYNTHESIS-STUTTGART, P952

[22]

PAGE PCB, 1992, TETRAHEDRON, V48, P5933

[23]

Perez E, 1996, HETEROCYCLES, V43, P539

[24]

SASSON Y, 1997, HDB PHASE TRANSFER C, V173, P288

[25]

STARKS CM, 1994, PHASE TRANSFER CATAL, P400

[26] INVITED REVIEW - DEVELOPMENTS IN MICROWAVE-ASSISTED ORGANIC-CHEMISTRY [J].

STRAUSS, CR ;

TRAINOR, RW .

AUSTRALIAN JOURNAL OF CHEMISTRY, 1995, 48 (10) :1665-1692

[27] N-ALKYLATION OF PRIMARY AND SECONDARY AMINES BY ALKYL HALIDES AND LITHIUM NAPHTHALENE [J].

SUGA, K ;

WATANABE, S ;

FUJITA, T ;

PAN, TP .

BULLETIN OF THE CHEMICAL SOCIETY OF JAPAN, 1969, 42 (12) :3606-+

[28]

Varma RS, 1997, AM CERAMIC SOC CERAM, V80, P357

[29]

*W CLOW LTD, 1984, VOG TXB PRACT ORG CH, P669

[30] A simple and efficient method for preparation of unsymmetrical sulfides [J].

Yin, JM ;

Pidgeon, C .

TETRAHEDRON LETTERS, 1997, 38 (34) :5953-5954

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