Total Synthesis of FR901483

被引：77

作者：

Carson, Cheryl A. ^{[1
]}

Kerr, Michael A. ^{[1
]}

机构：

[1] Univ Western Ontario, Dept Chem, London, ON N6A 5B7, Canada

来源：

ORGANIC LETTERS | 2009年 / 11卷 / 03期

基金：

加拿大自然科学与工程研究理事会;

关键词：

LITHIUM AMIDE BASES; POTENT IMMUNOSUPPRESSANT FR901483; DIASTEREOSELECTIVE SYNTHESIS; TRICYCLIC CORE; CYCLIC-KETONES; PYRROLIDINES; (-)-FR901483; CYCLOADDITION; 1,1-CYCLOPROPANEDIESTERS; CYCLIZATION;

D O I：

10.1021/ol802870c

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The architecturally sophisticated skeleton of the immunosuppressive alkaloid FR901483 was assembled via a process relying on the reaction of an in situ generated imine with a suitably disposed donor-acceptor cyclopropane. A short sequence of functional group transformations provided the natural product in an efficient manner.

引用

页码：777 / 779

页数：3

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