Pilot trial of albuterol in Duchenne and Becker muscular dystrophy

被引：47

作者：

Fowler, EG

Graves, MC

Wetzel, GT

Spencer, MJ

机构：

[1] Univ Calif Los Angeles, Dept Pediat, Duchenne Muscular Dystrophy Res Ctr, Los Angeles, CA 90095 USA

[2] Univ Calif Los Angeles, David Geffen Sch Med, Dept Orthopaed Surg, Los Angeles, CA USA

[3] Univ Calif Los Angeles, David Geffen Sch Med, Dept Neurol, Los Angeles, CA USA

[4] Univ Calif Los Angeles, David Geffen Sch Med, Dept Pediat, Los Angeles, CA USA

来源：

NEUROLOGY | 2004年 / 62卷 / 06期

关键词：

D O I：

10.1212/01.WNL.0000118530.71646.0F

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

The authors conducted a randomized, crossover, double-blind, placebo-controlled pilot study of albuterol in nine boys with dystrophinopathies. Primary outcomes were 1) isometric knee extensor and flexor strength; and 2) manual muscle testing (MMT). Isometric knee extensor strength and MMT scores were significantly higher in patients taking albuterol vs placebo. Therefore, 12-week treatment with extended-release albuterol may increase strength in patients with dystrophinopathies. A larger, double-blind, randomized study is necessary to confirm these results.

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收藏

页码：1006 / 1008

页数：3

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