Cell-specific and concentration-dependent actions of interleukin-1 in acute brain inflammation

被引：61

作者：

Pinteaux, Emmanuel ^{[1
]}

Trotter, Paula ^{[1
]}

Simi, Anastasia ^{[1
]}

机构：

[1] Univ Manchester, Fac Life Sci, Manchester M13 9PT, Lancs, England

来源：

CYTOKINE | 2009年 / 45卷 / 01期

基金：

英国医学研究理事会;

关键词：

Interleukin-1; Glia; Neurones; Neuro inflammation; Signalling; TUMOR-NECROSIS-FACTOR; NERVE GROWTH-FACTOR; MICROVESSEL ENDOTHELIAL-CELLS; HUMAN FETAL ASTROCYTES; NF-KAPPA-B; HIPPOCAMPAL SLICE CULTURES; INCREASES INTRACELLULAR CALCIUM; ANTERIOR HYPOTHALAMIC NEURONS; MESSENGER-RNA EXPRESSION; LONG-TERM POTENTIATION;

D O I：

10.1016/j.cyto.2008.10.008

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Interleukin (IL)-1 is a pivotal pro-inflammatory cytokine and an important mediator of both acute and chronic central nervous system (CNS) injuries. Despite intense research in CNS IL-1 biology over the past two decades, its precise mechanism of action in inflammatory responses to acute brain disorders remains largely unknown. in particular, much effort has been focussed on using in vitro approaches to better understand the cellular and signalling mechanisms of actions of IL-1, yet some discrepancies in the literature regarding the effects produced by IL-1 0 in in vitro paradigms of injury still exist, particularly as to whether IL-1 exerts neurotoxic or neuroprotective effects. Here we aim to review the cell-specific and concentration-dependent actions of IL-1 in brain cells, to depict the mechanism by which this cytokine induces neurotoxicity or neuroprotection in acute brain injury. (C) 2008 Elsevier Ltd. All rights reserved.

引用

页码：1 / 7

页数：7

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