Cell-specific and concentration-dependent actions of interleukin-1 in acute brain inflammation

被引：61

作者：

Pinteaux, Emmanuel ^{[1
]}

Trotter, Paula ^{[1
]}

Simi, Anastasia ^{[1
]}

机构：

[1] Univ Manchester, Fac Life Sci, Manchester M13 9PT, Lancs, England

来源：

CYTOKINE | 2009年 / 45卷 / 01期

基金：

英国医学研究理事会;

关键词：

Interleukin-1; Glia; Neurones; Neuro inflammation; Signalling; TUMOR-NECROSIS-FACTOR; NERVE GROWTH-FACTOR; MICROVESSEL ENDOTHELIAL-CELLS; HUMAN FETAL ASTROCYTES; NF-KAPPA-B; HIPPOCAMPAL SLICE CULTURES; INCREASES INTRACELLULAR CALCIUM; ANTERIOR HYPOTHALAMIC NEURONS; MESSENGER-RNA EXPRESSION; LONG-TERM POTENTIATION;

D O I：

10.1016/j.cyto.2008.10.008

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Interleukin (IL)-1 is a pivotal pro-inflammatory cytokine and an important mediator of both acute and chronic central nervous system (CNS) injuries. Despite intense research in CNS IL-1 biology over the past two decades, its precise mechanism of action in inflammatory responses to acute brain disorders remains largely unknown. in particular, much effort has been focussed on using in vitro approaches to better understand the cellular and signalling mechanisms of actions of IL-1, yet some discrepancies in the literature regarding the effects produced by IL-1 0 in in vitro paradigms of injury still exist, particularly as to whether IL-1 exerts neurotoxic or neuroprotective effects. Here we aim to review the cell-specific and concentration-dependent actions of IL-1 in brain cells, to depict the mechanism by which this cytokine induces neurotoxicity or neuroprotection in acute brain injury. (C) 2008 Elsevier Ltd. All rights reserved.

引用

页码：1 / 7

页数：7

共 113 条

[41] Regulation of astroglial-derived dopaminergic neurotrophic factors by interleukin-1 beta in the striatum of young and middle-aged mice [J].

Ho, A ;

Blum, M .

EXPERIMENTAL NEUROLOGY, 1997, 148 (01) :348-359

[42] CYTOKINE STIMULATION INCREASES INTRACELLULAR CALCIUM AND ALTERS THE RESPONSE TO QUISQUALATE IN CULTURED CORTICAL ASTROCYTES [J].

HOLLIDAY, J ;

GRUOL, DL .

BRAIN RESEARCH, 1993, 621 (02) :233-241

[43] Interleukin-1β induces a reactive astroglial phenotype via deactivation of the rho GTPase-rock axis [J].

John, GR ;

Chen, LF ;

Rivieccio, MA ;

Melendez-Vasquez, CV ;

Hartley, A ;

Brosnan, CF .

JOURNAL OF NEUROSCIENCE, 2004, 24 (11) :2837-2845

[44] IL-1β differentially regulates calcium wave propagation between primary human fetal astrocytes via pathways involving P2 receptors and gap junction channels [J].

John, GR ;

Scemes, E ;

Suadicani, SO ;

Liu, JSH ;

Charles, PC ;

Lee, SC ;

Spray, DC ;

Brosnan, CF .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1999, 96 (20) :11613-11618

[45] A novel role of interleukin-1-converting enzyme in cytokine-mediated inducible nitric oxide synthase gene expression:: Implications for neuroinflammatory diseases [J].

Juettler, Eric ;

Bonmann, Eckhard ;

Spranger, Matthias ;

Kolb-Bachofen, Victoria ;

Suschek, Christoph V. .

MOLECULAR AND CELLULAR NEUROSCIENCE, 2007, 34 (04) :612-620

[46] Interleukin-1β, but not IL-1α, mediates nerve growth factor secretion from rat astrocytes via type IIL-1 receptor [J].

Juric, DM ;

Carman-Krzan, M .

INTERNATIONAL JOURNAL OF DEVELOPMENTAL NEUROSCIENCE, 2001, 19 (07) :675-683

[47] Release of ciliary neurotrophic factor from cultured astrocytes and its modulation by cytokines [J].

Kamiguchi, H ;

Yoshida, K ;

Sagoh, M ;

Sasaki, H ;

Inaba, M ;

Wakamoto, H ;

Otani, M ;

Toya, S .

NEUROCHEMICAL RESEARCH, 1995, 20 (10) :1187-1193

[48] INTERLEUKIN-1-BETA INHIBITS LONG-TERM POTENTIATION IN THE CA3 REGION OF MOUSE HIPPOCAMPAL SLICES [J].

KATSUKI, H ;

NAKAI, S ;

HIRAI, Y ;

AKAJI, K ;

KISO, Y ;

SATOH, M .

EUROPEAN JOURNAL OF PHARMACOLOGY, 1990, 181 (03) :323-326

[49] INTERLEUKIN-1-BETA INCREASES PROSTAGLANDIN-E2 IN RAT ASTROCYTE CULTURES - MODULATORY EFFECT OF NEUROPEPTIDES [J].

KATSUURA, G ;

GOTTSCHALL, PE ;

DAHL, RR ;

ARIMURA, A .

ENDOCRINOLOGY, 1989, 124 (06) :3125-3127

[50] TNFα and IL-1β mediate intercellular adhesion molecule-1 induction via microglia-astrocyte interaction in CNS radiation injury [J].

Kyrkanides, S ;

Olschowka, JA ;

Williams, JP ;

Hansen, JT ;

O'Banion, MK .

JOURNAL OF NEUROIMMUNOLOGY, 1999, 95 (1-2) :95-106

← 1 2 3 4 5 6 7 8 9 10 →