Incorporation and characterization of abasic and phenyl residues in peptide nucleic acids

被引：12

作者：

Challa, H

Woski, SA

机构：

[1] Univ Alabama, Dept Chem, Tuscaloosa, AL 35487 USA

[2] Univ Alabama, Coalit Biomol Prod, Tuscaloosa, AL 35487 USA

来源：

TETRAHEDRON LETTERS | 1999年 / 40卷 / 48期

关键词：

D O I：

10.1016/S0040-4039(99)01781-5

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The N-(2-aminoethyl)glycine backbone unit of PNA has been derivatized with phenylacetic acid and acetic acid moieties to produce monomers for incorporation into PNAs. As expected, oligomers containing these residues form PNA-DNA double helices that are destabilized compared to the unsubstituted duplexes. However, unlike the analogous substitutions in DNA, these residues show very little sequence specificity. (C) 1999 Elsevier Science Ltd. All rights reserved.

引用

页码：8333 / 8336

页数：4

共 17 条

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