A novel short convergent entry into himbacine derivatives

被引：12

作者：

Van Cauwenberge, G

Gao, LJ

Van Haver, D

Milanesio, M

Viterbo, D

De Clercq, PJ

机构：

[1] State Univ Ghent, Dept Organ Chem, B-9000 Ghent, Belgium

[2] Univ Piemonte Orientale A Avogadro, Dipartimento Sci & Tecnol Avanzate, I-15100 Alessandria, Italy

来源：

ORGANIC LETTERS | 2002年 / 4卷 / 09期

关键词：

D O I：

10.1021/ol025801g

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The IMDA reaction of 9 leads with good stereoselectivity to exo-adduct 10b. The functionalized ABC-ring core in 10 is well suited for the convergent synthesis of analogues of himbacine, a naturally occurring M-2 selective muscarine receptor antagonist, as illustrated with the further synthesis of the dehydro-derivative 5.

引用

页码：1579 / 1582

页数：4

共 38 条

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