Copper-catalyzed oxidative coupling of benzylic C-H bonds with 1,3-dicarbonyl compounds

被引：86

作者：

Borduas, Nadine ^{[1
]}

Powell, David A. ^{[1
]}

机构：

[1] Merck Frosst Ctr Therapeut Res, Kirkland, PQ H9H 3L1, Canada

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2008年 / 73卷 / 19期

关键词：

D O I：

10.1021/jo801322p

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A copper-catalyzed oxidative coupling of benzylic C-H bonds with 1,3-dicarbonyl compounds is described. The reaction utilizes an inexpensive copper catalyst - oxidant system that is suitable for the coupling of a range of benzylic C-H bonds with various 1,3-dicarbonyl compounds. Kinetic isotope studies support a mechanism involving a benzylic hydrogen abstraction.

引用

页码：7822 / 7825

页数：4

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