Vitamin A insufficiency accelerates the decrease in the number of sperm induced by an environmental disruptor, bisphenol A, in neonatal mice

被引:11
作者
Nakahashi, K [1 ]
Matsuda, M [1 ]
Mori, T [1 ]
机构
[1] Univ Tokyo, Grad Sch Sci, Dept Biol Sci, Tokyo 1130033, Japan
关键词
D O I
10.2108/zsj.18.819
中图分类号
Q95 [动物学];
学科分类号
071002 ;
摘要
Exposure of neonatal mice to an estrogenic endocrine disruptor, bisphenol A, resulted in a malfunction of the testes when the animals became adults. The effect of bisphenol A was cancelled out by concurrent administration of retinol acetate, a naturally occurring metabolite of vitamin A. In contrast, the effect of endocrine disruption became more severe in mice neonatally exposed to bisphenol A and nursed by mothers fed a vitamin A-deficient diet only a few days before and after parturition. These results clearly show that maternal vitamin A is important for relieving in a baby the effect of endocrine disruption caused by environmental xenoestrogens, and suggest that the changes in the content of vitamin A and similar physiological factors in the habitat may be worth considering in studies on environmental disruptors.
引用
收藏
页码:819 / 821
页数:3
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