A convenient new route to 4-substituted benzo[de][3,6]phenanthrolin-6(6H)-ones:: Important intermediates in the synthesis of ring-A analogues of the cytotoxic marine alkaloid ascididemin.

被引：10

作者：

Copp, BR ^{[1
]}

Hansen, RP ^{[1
]}

Appleton, DR ^{[1
]}

Lindsay, BS ^{[1
]}

Squire, CJ ^{[1
]}

Clark, GR ^{[1
]}

Rickard, CEF ^{[1
]}

机构：

[1] Univ Auckland, Dept Chem, Auckland, New Zealand

来源：

SYNTHETIC COMMUNICATIONS | 1999年 / 29卷 / 15期

关键词：

D O I：

10.1080/00397919908086428

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

4-ethylthio- and 4-(4 "-methylphenylthio)benzo[de][3,6]phenanthrolin-6(6H)-one have been synthesised in 4 steps from benzoquinone and then readily converted to the 4-amino (6d) and 4-methoxy (6c) analogues by nucleophilic substitution. Further elaboration of 6d leads to the synthesis of 11-hydroxyascididemin, which we have found to exhibit antiviral activity in vitro.

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页码：2665 / 2676

页数：12

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