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Cyanamide in isocyanide-based MCRs

被引：26
作者：
Dömling, A
Herdtweck, E
Heck, S
机构：
[1] ABC Pharma, D-81243 Munich, Germany
[2] Tech Univ Munich, D-8046 Garching, Germany
来源：
TETRAHEDRON LETTERS | 2006年 / 47卷 / 11期
关键词：
MCR; Ugi reaction; cyanamide; isocyanide; combinatorial chemistry;
D O I：
10.1016/j.tetlet.2006.01.032
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Cyanamide reacts with enamines and isocyanides in the presence of Lewis acids to give the hitherto unknown scaffold 2-amino-(N-cyano)-amidines. Preliminary scope and limitation of this novel reaction is described. (c) 2006 Elsevier Ltd. All rights reserved.
引用
收藏
页码：1745 / 1747
页数：3
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