Sex chromosome specialization and degeneration in mammals

被引:435
作者
Graves, JAM [1 ]
机构
[1] Australian Natl Univ, Res Sch Biol Sci, Canberra, ACT 2601, Australia
关键词
D O I
10.1016/j.cell.2006.02.024
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Sex chromosomes-particularly the human Y-have been a source of fascination for decades because of their unique transmission patterns and their peculiar cytology. The outpouring of genomic data confirms that their atypical structure and gene composition break the rules of genome organization, function, and evolution. The X has been shaped by dosage differences to have a biased gene content and to be subject to inactivation in females. The Y chromosome seems to be a product of a perverse evolutionary process that does not select the fittest Y, which may cause its degradation and ultimate extinction.
引用
收藏
页码:901 / 914
页数:14
相关论文
共 80 条
[51]   300 million years of conserved synteny between chicken Z and human chromosome 9 [J].
Nanda, I ;
Shan, ZH ;
Schartl, M ;
Burt, DW ;
Koehler, M ;
Nothwang, HG ;
Grützner, F ;
Paton, IR ;
Windsor, D ;
Dunn, I ;
Engel, W ;
Staeheli, P ;
Mizuno, S ;
Haaf, T ;
Schmid, M .
NATURE GENETICS, 1999, 21 (03) :258-259
[52]  
Ohno S., 1967, SEX CHROMOSOMES SEX
[53]  
ORR HA, 1989, GENETICS, V121, P527
[54]   THE SEX-DETERMINING REGION OF THE HUMAN Y-CHROMOSOME ENCODES A FINGER PROTEIN [J].
PAGE, DC ;
MOSHER, R ;
SIMPSON, EM ;
FISHER, EMC ;
MARDON, G ;
POLLACK, J ;
MCGILLIVRAY, B ;
DELACHAPELLE, A ;
BROWN, LG .
CELL, 1987, 51 (06) :1091-1104
[55]   Characterisation of the marsupial-specific ATRY gene:: Implications for the evolution of male-specific function [J].
Park, DJ ;
Pask, AJ ;
Huynh, K ;
Harley, VR ;
Renfree, MB ;
Graves, JAM .
GENE, 2005, 362 :29-36
[56]   The human sex-reversing ATRX gene has a homologue on the marsupial Y chromosome, ATRY: Implications for the evolution of mammalian sex determination [J].
Pask, A ;
Renfree, MB ;
Graves, JAM .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2000, 97 (24) :13198-13202
[57]   The master sex-determination locus in threespine sticklebacks is on a nascent Y chromosome [J].
Peichel, CL ;
Ross, JA ;
Matson, CK ;
Dickson, M ;
Grimwood, J ;
Schmutz, J ;
Myers, RM ;
Mori, S ;
Schluter, D ;
Kingsley, DM .
CURRENT BIOLOGY, 2004, 14 (16) :1416-1424
[58]   Sox9 is sufficient for functional testis development producing fertile male mice in the absence of Sry [J].
Qin, YJ ;
Bishop, CE .
HUMAN MOLECULAR GENETICS, 2005, 14 (09) :1221-1229
[59]   Sex and the genome [J].
Reinke, V .
NATURE GENETICS, 2004, 36 (06) :548-549
[60]   A family of human Y chromosomes has dispersed throughout northern Eurasia despite a 1.8-Mb deletion in the azoospermia factor c region [J].
Repping, S ;
van Daalen, SKM ;
Korver, CM ;
Brown, LG ;
Marszalek, JD ;
Gianotten, J ;
Oates, RD ;
Silber, S ;
van der Veen, F ;
Page, DC ;
Rozen, S .
GENOMICS, 2004, 83 (06) :1046-1052