Sex chromosome specialization and degeneration in mammals

被引：435

作者：

Graves, JAM ^{[1
]}

机构：

[1] Australian Natl Univ, Res Sch Biol Sci, Canberra, ACT 2601, Australia

来源：

CELL | 2006年 / 124卷 / 05期

关键词：

D O I：

10.1016/j.cell.2006.02.024

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Sex chromosomes-particularly the human Y-have been a source of fascination for decades because of their unique transmission patterns and their peculiar cytology. The outpouring of genomic data confirms that their atypical structure and gene composition break the rules of genome organization, function, and evolution. The X has been shaped by dosage differences to have a biased gene content and to be subject to inactivation in females. The Y chromosome seems to be a product of a perverse evolutionary process that does not select the fittest Y, which may cause its degradation and ultimate extinction.

引用

页码：901 / 914

页数：14

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