Regulation of translation via TOR signaling:: Insights from Drosophila melanogaster

被引:22
作者
Miron, M
Sonenberg, N
机构
[1] McGill Univ, Dept Biochem, Montreal, PQ, Canada
[2] McGill Univ, McGill Canc Ctr, Montreal, PQ, Canada
关键词
rapamycin; target of rapamycin; insulin-like signaling; translational control;
D O I
10.1093/jn/131.11.2988S
中图分类号
R15 [营养卫生、食品卫生]; TS201 [基础科学];
学科分类号
100403 ;
摘要
The target of rapamycin (TOR) proteins are large protein kinases evolutionarily conserved from yeast to human. A large body of evidence demonstrates that TOR proteins function in a nutrient-sensing checkpoint whose role is to restrict growth under conditions of low nutrient availability. Under such conditions, TOR blocks the transmission of growth-promoting signals from extracellular stimuli. Recent data obtained by genetic studies in the fruit fly Drosophila melanogaster demonstrate the importance of both insulin-like signaling and TOR signaling in promoting growth. Importantly, these studies identified a major downstream target of TOR and insulin-like signaling as the translational machinery.
引用
收藏
页码:2988S / 2993S
页数:6
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