A stereoselective synthesis for the (5Z,9Z)-14-methyl-5,9-pentadecadienoic acid and its monounsaturated analog (Z)-14-methyl-9-pentadecenoic acid

被引：8

作者：

Carballeira, NM ^{[1
]}

Sanabria, D ^{[1
]}

Ayala, NL ^{[1
]}

Cruz, C ^{[1
]}

机构：

[1] Univ Puerto Rico, Dept Chem, San Juan, PR 00931 USA

来源：

TETRAHEDRON LETTERS | 2004年 / 45卷 / 19期

基金：

美国国家卫生研究院;

关键词：

fatty acids; topoisomerase I; synthesis; alkyne coupling;

D O I：

10.1016/j.tetlet.2004.03.078

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A stereoselective synthesis for the (5Z,9Z)-14-methyl-5,9-pentadecadienoic acid and the monounsaturated analog (Z)-14-methyl-9-pentadecenoic acid was accomplished in six to seven steps where double alkyne coupling was the key step. This synthesis will facilitate the study of the topoisomerase I inhibitory profile of this important class of fatty acids. (C) 2004 Elsevier Ltd. All rights reserved.

引用

页码：3761 / 3763

页数：3

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