Topoisomerase I inhibitors from the Streptomyces sp. strain KM86-9B isolated from a marine sponge

被引：20

作者：

Lee, HK

Lee, DS

Lim, J

Kim, JS

Im, KS

Jung, JH ^{[1
]}

机构：

[1] Pusan Natl Univ, Coll Pharm, Pusan 609735, South Korea

[2] Korea Ocean Res & Dev Inst, Microbiol Lab, Ansan 425600, South Korea

来源：

ARCHIVES OF PHARMACAL RESEARCH | 1998年 / 21卷 / 06期

关键词：

topoisomerase I inhibitor; marine actinomycete; iso-fatty acids; anteiso-fatty acids; marine sponge;

D O I：

10.1007/BF02976766

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The crude extract of Streptomyces sp. strain KM86-9B, isolated from a marine sponge, displayed significant inhibition on topoisomerase I activity. investigation of the causative components by bioactivity-directed fractionation resulted in the isolation of a series of iso- and anteiso-fatty acids.

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收藏

页码：729 / 733

页数：5

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