ImmPort, toward repurposing of open access immunological assay data for translational and clinical research

被引:627
作者
Bhattacharya, Sanchita [1 ]
Dunn, Patrick [2 ]
Thomas, Cristel G. [2 ]
Smith, Barry [3 ]
Schaefer, Henry [4 ]
Chen, Jieming [1 ]
Hu, Zicheng [1 ]
Zalocusky, Kelly A. [1 ]
Shankar, Ravi D. [5 ]
Shen-Orr, Shai S. [6 ]
Thomson, Elizabeth [2 ]
Wiser, Jeffrey [2 ]
Butte, Atul J. [1 ]
机构
[1] Univ Calif San Francisco, Inst Computat Hlth Sci, San Francisco, CA 94158 USA
[2] Northrop Grumman Hlth Solut, Rockville, MD 20850 USA
[3] Univ Buffalo, Dept Philosophy, Buffalo, NY 14260 USA
[4] Enterprise Sci & Comp Inc, Rockville, MD 20850 USA
[5] Stanford Univ, Dept Med, Sch Med, Stanford, CA 94305 USA
[6] Technion Israel Inst Technol, Dept Immunol, Fac Med, IL-3200003 Haifa, Israel
关键词
PROTEIN ONTOLOGY; CYTOMETRY DATA; TRIAL DATA; REPRESENTATION; ENTITIES; SUBSETS; NETWORK; VACCINE;
D O I
10.1038/sdata.2018.15
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
070301 [无机化学]; 070403 [天体物理学]; 070507 [自然资源与国土空间规划学]; 090105 [作物生产系统与生态工程];
摘要
Immunology researchers are beginning to explore the possibilities of reproducibility, reuse and secondary analyses of immunology data. Open-access datasets are being applied in the validation of the methods used in the original studies, leveraging studies for meta-analysis, or generating new hypotheses. To promote these goals, the ImmPort data repository was created for the broader research community to explore the wide spectrum of clinical and basic research data and associated findings. The ImmPort ecosystem consists of four components-Private Data, Shared Data, Data Analysis, and Resources-for data archiving, dissemination, analyses, and reuse. To date, more than 300 studies have been made freely available through the Shared Data portal (immport. org/immportopen), which allows research data to be repurposed to accelerate the translation of new insights into discoveries.
引用
收藏
页数:9
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