High-Yielding Synthesis of the Anti-Influenza Neuramidase Inhibitor (-)-Oseltamivir by Three "One-Pot" Operations

被引：340

作者：

Ishikawa, Hayato ^{[1
]}

Suzuki, Takaki ^{[1
]}

Hayashi, Yujiro ^{[1
,2
]}

机构：

[1] Tokyo Univ Sci, Dept Ind Engn, Fac Engn, Shinjyuku Ku, Tokyo 1628601, Japan

[2] Tokyo Univ Sci, Sci & Technol Res Inst, Tokyo 1628601, Japan

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2009年 / 48卷 / 07期

关键词：

antiviral agents; domino reactions; organocatalysis; oseltamivir; Tamiflu; DIPHENYLPROLINOL SILYL ETHER; ASYMMETRIC MICHAEL REACTION; OSELTAMIVIR; TAMIFLU; PHOSPHATE; CATALYST; ALDEHYDES; FUNCTIONALIZATION; ORGANOCATALYSIS; ACETALDEHYDE;

D O I：

10.1002/anie.200804883

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Taking shortcuts: A remarkably short and high-yielding asymmetric total synthesis of (-)-oseltamivir takes advantage of organocatalysis and single-pot domino operations. The target, known as the drug Tamiflu, is prepared efficiently in a short time, and also its derivatives can be synthesized effectively. © 2009 Wiley-VCH Verleg GmbH & Co. KGaA.

引用

页码：1304 / 1307

页数：4

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