The Impact of Genetic Research on our Understanding of Normal Cognitive Ageing: 1995 to 2009

被引：74

作者：

Payton, Antony ^{[1
]}

机构：

[1] Univ Manchester, Ctr Integrated Genom Med Res, Manchester M13 9PT, Lancs, England

来源：

NEUROPSYCHOLOGY REVIEW | 2009年 / 19卷 / 04期

关键词：

Cognitive ability; Cognitive decline; Genetic; Polymorphism; Elderly; QUANTITATIVE TRAIT LOCUS; DOPAMINE D2 RECEPTOR; AGE-RELATED DECLINE; FACTOR VAL66MET POLYMORPHISM; ACTIVITY-DEPENDENT SECRETION; EPISODIC MEMORY PERFORMANCE; MESSENGER-RNA EXPRESSION; VASCULAR RISK-FACTORS; NEUROTROPHIC-FACTOR; OXIDATIVE STRESS;

D O I：

10.1007/s11065-009-9116-z

中图分类号：

B849 [应用心理学];

学科分类号：

040203 ;

摘要：

Identifying the risk factors for individual differences in age-related cognitive ability and decline is amongst the greatest challenges facing the healthcare of older people. Cognitive impairment caused by "normal ageing" is a major contributor towards overall cognitive deficit in the elderly and a process that exhibits substantial inter- and intra-individual differences. Both cognitive ability and its decline with age are influenced by genetic variation that may act independently or via epistasis/gene-environment interaction. Over the past fourteen years genetic research has aimed to identify the polymorphisms responsible for high cognitive functioning and successful cognitive ageing. Unfortunately, during this period a bewildering array of contrasting reports have appeared in the literature that have implicated over 50 genes with effect sizes ranging from 0.1 to 21%. This review will provide a comprehensive account of the studies performed on cognitively healthy individuals, from the first study conducted in 1995 to present. Based on current knowledge the strong and weak methodologies will be identified and suggestions for future study design will be presented.

引用

页码：451 / 477

页数：27

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