Asymmetric synthesis of (S)-(-)-acromelobinic acid

被引：8

作者：

Adamczyk, M ^{[1
]}

Akireddy, SR ^{[1
]}

Reddy, RE ^{[1
]}

机构：

[1] Abbott Labs, Dept Chem, Div Diagnost, Abbott Pk, IL 60064 USA

来源：

TETRAHEDRON-ASYMMETRY | 2001年 / 12卷 / 17期

关键词：

D O I：

10.1016/S0957-4166(01)00414-1

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

A total synthesis of (S)-(-)-acromelobinic acid 2, which was isolated from elitocybe acromelalga, was achieved via an asymmetric hydrogenation protocol. Dehydroamino acid derivative 12 was prepared from 2.5-lutidine 5 and subjected to asymmetric hydrogenation using (S,S)-[Rh(Et-DuPHOS)(COD)]BF4 to give the (S)-(+)-pyridylalanine derivative 13 in 93% yield and > 96% e.e. Removal of the protecting groups in (S)-(+)-13 afforded (S)-(-)-acromelobinic acid 2. (C) 2001 Elsevier Science Ltd. All rights reserved.

引用

页码：2385 / 2387

页数：3

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