Detection and distinguishability of leukemia cancer cells based on Au nanoparticles modified electrodes

被引：17

作者：

Hu, Hong-Li ^{[1
]}

Jiang, Hui ^{[1
]}

Wang, Xue-Mei ^{[1
]}

Chen, Bao-An ^{[2
]}

机构：

[1] Southeast Univ, State Key Lab Bioelect, Chien Shiung Wu Lab, Nanjing 210096, Peoples R China

[2] Southeast Univ, Zhongda Hosp, Sch Clin Med, Nanjing 210096, Peoples R China

来源：

ELECTROCHEMISTRY COMMUNICATIONS | 2008年 / 10卷 / 08期

基金：

中国国家自然科学基金;

关键词：

Au nanoparticles; leukemia cancer cells; electrodeposition; electrochemical biosensors;

D O I：

10.1016/j.elecom.2008.05.030

中图分类号：

O646 [电化学、电解、磁化学];

学科分类号：

081704 ;

摘要：

The Au nanoparticles (Au NPs) modified interface has been fabricated by multi-potential step electrode-position in this study. Based on the nano-Au interface, we have proposed an electrochemical approach to detect the cancer cell numbers sensitively with a detection limit of about 500 cells. More interestingly, the drug sensitive leukemia K562 cells and drug resistant leukemia K562/adriamycin could be electrochemically distinguished on the interface by the oxidation potential, which did not show any evident differences on the bare electrode. These results indicate the promising application of this nano-interface for constructing the unlabeled potential-discriminative cell biosensors. (C) 2008 Elsevier B.V. All rights reserved.

引用

页码：1121 / 1124

页数：4

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