Gadolinium neutron-capture therapy using novel gadopentetic acid-chitosan complex nanoparticles: in vivo growth suppression of experimental melanoma solid tumor

被引:91
作者
Tokumitsu, H
Hiratsuka, J
Sakurai, Y
Kobayashi, T
Ichikawa, H
Fukumori, Y
机构
[1] Kobe Gakuin Univ, Fac Pharmaceut Sci, Nishi Ku, Kobe, Hyogo 6512180, Japan
[2] Kawasaki Med Sch, Dept Radiat Oncol, Kurashiki, Okayama 7010192, Japan
[3] Kyoto Univ, Inst Res Reactor, Kumatori, Osaka 5900494, Japan
关键词
neutron-capture therapy; gadolinium; nanoparticle; chitosan; gadopentetic acid;
D O I
10.1016/S0304-3835(99)00388-2
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
The potential of gadolinium neutron-capture therapy (Gd-NCT) for cancer was evaluated using chitosan nanoparticles as a novel gadolinium device. The nanoparticles, incorporating 1200 mu g of natural gadolinium, were administered intratumorally twice in mice bearing subcutaneous B16F10 melanoma. The thermal neutron irradiation was performed for the tumor site, with the fluence of 6.32 x 10(12) neutrons/cm(2), 8 h after the second gadolinium administration. After the irradiation, the tumor growth in the nanoparticle-administered group was significantly suppressed compared to that in the gadopentetate solution-administered group, despite radioresistance of melanoma and the smaller Gd dose than that administered in past Gd-NCT trials. This study demonstrated the potential usefulness of Gd-NCT using gadolinium-loaded nanoparticles. (C) 2000 Elsevier Science Ireland Ltd. All rights reserved.
引用
收藏
页码:177 / 182
页数:6
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