Triple Stimulus-Responsive Polypeptide Nanoparticles That Enhance Intratumoral Spatial Distribution

被引：99

作者：

Callahan, Daniel J. ^{[1
,2
]}

Liu, Wenge ^{[1
]}

Li, Xinghai ^{[1
]}

Dreher, Matthew R. ^{[3
]}

Hassouneh, Wafa ^{[1
,2
]}

Kim, Minkyu ^{[2
,4
]}

Marszalek, Piotr ^{[2
,4
]}

Chilkoti, Ashutosh ^{[1
,2
]}

机构：

[1] Duke Univ, Dept Biomed Engn, Durham, NC 27708 USA

[2] Duke Univ, Ctr Biol Inspired Mat & Mat Syst, Durham, NC 27708 USA

[3] NCI, Ctr Intervent Oncol, Ctr Clin, NIH, Bethesda, MD 20892 USA

[4] Duke Univ, Dept Mech Engn & Mat Sci, Durham, NC 27708 USA

来源：

NANO LETTERS | 2012年 / 12卷 / 04期

基金：

美国国家科学基金会;

关键词：

Polypeptides; block copolymers; stimulus-responsive; pH responsive; tumor drug delivery; ELASTIN-LIKE POLYPEPTIDES; PH-SENSITIVE IMMUNOLIPOSOMES; INTRACELLULAR DRUG-DELIVERY; PROTEIN-BASED POLYMERS; SOLID TUMORS; PACLITAXEL DELIVERY; MICELLES; DOXORUBICIN; SYSTEM; DESTABILIZATION;

D O I：

10.1021/nl300630c

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

To address the limited tumor penetration of nanoparticle drug delivery vehicles, we report the first pH-responsive polypeptide micelle that dissociates at the low extracellular pH of solid tumors. This histidine-rich elastin-like polypeptide block copolymer self-assembles at 37 degrees C into spherical micelles that are stabilized by Zn2+ and are disrupted as the pH drops from 7.4 to 6.4. These pH-sensitive micelles demonstrate better in vivo penetration and distribution in tumors than a pH-insensitive control.

引用

页码：2165 / 2170

页数：6

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