Biaryl Construction via Ni-Catalyzed C-O Activation of Phenolic Carboxylates

被引:337
作者
Guan, Bing-Tao [1 ,2 ]
Wang, Yang [1 ,2 ]
Li, Bi-Jie [1 ,2 ]
Yu, Da-Gang [1 ,2 ]
Shi, Zhang-Jie [1 ,2 ,3 ]
机构
[1] Peking Univ, BNLMS, Beijing 100871, Peoples R China
[2] Peking Univ, Minist Educ, Key Lab Bioorgan Chem & Mol Engn, Beijing 100871, Peoples R China
[3] Chinese Acad Sci, State Key Lab Oganomet Chem, Shanghai 200032, Peoples R China
关键词
D O I
10.1021/ja8056503
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
Biaryl scaffolds were constructed via Ni-catalyzed aryl C-O activation by avoiding cleavage of the more reactive acyl C-O bond aryl carboxylates. Now aryl esters, in general, can be successfully employed in cross-coupling reactions for the first time. The substrate scope and synthetic utility of the chemistry were demonstrated by the syntheses of more than 40 biaryls and by constructing complex organic molecules. Water was observed to play an important role in facilitating this transformation.
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页码:14468 / +
页数:4
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