Phenanthridine Synthesis through Iron-Catalyzed Intramolecular N-Arylation of O-Acetyl Oxime

被引：105

作者：

Deb, Indubhusan ^{[1
]}

Yoshikai, Naohiko ^{[1
]}

机构：

[1] Nanyang Technol Univ, Sch Phys & Math Sci, Div Chem & Biol Chem, Singapore 637371, Singapore

来源：

ORGANIC LETTERS | 2013年 / 15卷 / 16期

基金：

新加坡国家研究基金会;

关键词：

RADICAL CYCLIZATION; BIOLOGICAL-ACTIVITY; DIOXIME OXALATES; IMINYL RADICALS; AROMATIC IMINES; ARYL CHLORIDES; DERIVATIVES; ACTIVATION; REAGENTS; NITROGEN;

D O I：

10.1021/ol4020392

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

O-Acetyl oximes derived from 2'-arylacetophenones undergo N-O bond cleavage/intramolecular N-arylation in the presence of a catalytic amount of iron(III) acetylacetonate in acetic acid. In combination with the conventional cross-coupling or directed C-H arylation, the reaction offers a convenient route to substituted phenanthridines.

引用

页码：4254 / 4257

页数：4

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