Cobalt-Catalyzed Ortho-Arylation of Aromatic Imines with Aryl Chlorides

被引：74

作者：

Gao, Ke ^{[1
]}

Lee, Pin-Sheng ^{[1
]}

Long, Chong ^{[1
]}

Yoshikai, Naohiko ^{[1
]}

机构：

[1] Nanyang Technol Univ, Sch Phys & Math Sci, Div Chem & Biol Chem, Singapore 637371, Singapore

来源：

ORGANIC LETTERS | 2012年 / 14卷 / 16期

基金：

新加坡国家研究基金会;

关键词：

C-H BOND; CROSS-COUPLING REACTIONS; CARBON-HYDROGEN BONDS; GRIGNARD-REAGENTS; ACTIVATION; IRON; METAL; FUNCTIONALIZATION; ARENES; HALIDES;

D O I：

10.1021/ol301934y

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An ortho-arylation reaction of aromatic imines with aryl chlorides has been achieved using a cobalt N-heterocyclic carbene catalyst in combination with a neopentyl Grignard reagent. The reaction takes place at room temperature to afford biaryl products in moderate to good yields.

引用

页码：4234 / 4237

页数：4

共 52 条

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