Multicolor quantum dots for molecular diagnostics of cancer

被引：234

作者：

Smith, AM

Dave, S

Nie, SM

True, L

Gao, XH ^{[1
]}

机构：

[1] Univ Washington, Dept Bioengn, Seattle, WA 98195 USA

[2] Emory Univ, Dept Biomed Engn, Atlanta, GA 30322 USA

[3] Georgia Inst Technol, Atlanta, GA 30322 USA

[4] Emory Univ, Dept Chem, Atlanta, GA 30322 USA

[5] Winship Canc Inst, Atlanta, GA 30322 USA

[6] Univ Washington, Dept Pathol, Seattle, WA 98195 USA

来源：

EXPERT REVIEW OF MOLECULAR DIAGNOSTICS | 2006年 / 6卷 / 02期

关键词：

biosensor; cancer; imaging; immunohistochemistry; in vivo; multiplex; nanotechnology; quantum dot; toxicity;

D O I：

10.1586/14737159.6.2.231

中图分类号：

R36 [病理学];

学科分类号：

100104 ;

摘要：

In the pursuit of sensitive and quantitative methods to detect and diagnose cancer, nanotechnology has been identified as a field of great promise. Semiconductor quantum dots are nanoparticles with intense, stable fluorescence, and could enable the detection of tens to hundreds of cancer biomarkers in blood assays, on cancer tissue biopsies, or as contrast agents for medical imaging. With the emergence of gene and protein profiling and microarray technology, high-throughput screening of biomarkers has generated databases of genomic and expression data for certain cancer types, and has identified new cancer-specific markers. Quantum dots have the potential to expand this in vitro analysis, and extend it to cellular, tissue and whole-body multiplexed cancer biomarker imaging.

引用

页码：231 / 244

页数：14

共 77 条

[1] Nanocrystal targeting in vivo [J].