BRCA1 and BRCA2 in hereditary breast cancer

被引：24

作者：

Scully, R

Puget, N

机构：

[1] Beth Israel Deaconess Med Ctr, Canc Biol Program, Dept Hematol Oncol, Boston, MA 02215 USA

[2] Harvard Univ, Sch Med, Boston, MA 02215 USA

来源：

BIOCHIMIE | 2002年 / 84卷 / 01期

关键词：

breast cancer; DNA repair; homologous recombination; tumor suppressor genes; BRCA1; BRCA2;

D O I：

10.1016/S0300-9084(01)01359-1

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The hereditary breast and ovarian cancer susceptibility genes, BRCA1 and BRCA2, have established roles in genome integrity maintenance and in the control of homologous recombination. Recent work has produced valuable insights into the mechanisms of action of the gene products. This review summarizes some of these advances, and attempts to place them in the context of known functions of the genes. (C) 2002 Societe francaise de biochimie et biologie moleculaire / Editions scientifiques et medicales Elsevier SAS.

引用

页码：95 / 102

页数：8

共 126 条

[111]

Wang Y, 2000, GENE DEV, V14, P927

[112] Insights into the functions of BRCA1 and BRCA2 [J].

Welcsh, PL ;

Owens, KN ;

King, MC .

TRENDS IN GENETICS, 2000, 16 (02) :69-74

[113] Localization of human BRCA1 and its loss in high-grade, non-inherited breast carcinomas [J].

Wilson, CA ;

Ramos, L ;

Villaseñor, MR ;

Anders, KH ;

Press, MF ;

Clarke, K ;

Karlan, B ;

Chen, JJ ;

Scully, R ;

Livingston, D ;

Zuch, RH ;

Kanter, MH ;

Cohen, S ;

Calzone, FJ ;

Slamon, DJ .

NATURE GENETICS, 1999, 21 (02) :236-240

[114] RAD51 interacts with the evolutionarily conserved BRC motifs in the human breast cancer susceptibility gene brca2 [J].

Wong, AKC ;

Pero, R ;

Ormonde, PA ;

Tavtigian, SV ;

Bartel, PL .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1997, 272 (51) :31941-31944

[115] LOCALIZATION OF A BREAST-CANCER SUSCEPTIBILITY GENE, BRCA2, TO CHROMOSOME 13Q12-13 [J].

WOOSTER, R ;

NEUHAUSEN, SL ;

MANGION, J ;

QUIRK, Y ;

FORD, D ;

COLLINS, N ;

NGUYEN, K ;

SEAL, S ;

TRAN, T ;

AVERILL, D ;

FIELDS, P ;

MARSHALL, G ;

NAROD, S ;

LENOIR, GM ;

LYNCH, H ;

FEUNTEUN, J ;

DEVILEE, P ;

CORNELISSE, CJ ;

MENKO, FH ;

DALY, PA ;

ORMISTON, W ;

MCMANUS, R ;

PYE, C ;

LEWIS, CM ;

CANNONALBRIGHT, LA ;

PETO, J ;

PONDER, BAJ ;

SKOLNICK, MH ;

EASTON, DF ;

GOLDGAR, DE ;

STRATTON, MR .

SCIENCE, 1994, 265 (5181) :2088-2090

[116] IDENTIFICATION OF THE BREAST-CANCER SUSCEPTIBILITY GENE BRCA2 [J].

WOOSTER, R ;

BIGNELL, G ;

LANCASTER, J ;

SWIFT, S ;

SEAL, S ;

MANGION, J ;

COLLINS, N ;

GREGORY, S ;

GUMBS, C ;

MICKLEM, G ;

BARFOOT, R ;

HAMOUDI, R ;

PATEL, S ;

RICE, C ;

BIGGS, P ;

HASHIM, Y ;

SMITH, A ;

CONNOR, F ;

ARASON, A ;

GUDMUNDSSON, J ;

FICENEC, D ;

KELSELL, D ;

FORD, D ;

TONIN, P ;

BISHOP, DT ;

SPURR, NK ;

PONDER, BAJ ;

EELES, R ;

PETO, J ;

DEVILEE, P ;

CORNELISSE, C ;

LYNCH, H ;

NAROD, S ;

LENOIR, G ;

EGILSSON, V ;

BARKADOTTIR, RB ;

EASTON, DF ;

BENTLEY, DR ;

FUTREAL, PA ;

ASHWORTH, A ;

STRATTON, MR .

NATURE, 1995, 378 (6559) :789-792

[117] Identification of a RING protein that can interact in vivo with the BRCA1 gene product [J].

Wu, LJC ;

Wang, ZW ;

Tsan, JT ;

Spillman, MA ;

Phung, A ;

Xu, XL ;

Yang, MCW ;

Hwang, LY ;

Bowcock, AM ;

Baer, R .

NATURE GENETICS, 1996, 14 (04) :430-440

[118]

WU X, 2000, SCIENCE, V289, pA11

[119] Deficiency of human BRCA2 leads to impaired homologous recombination but maintains normal nonhomologous end joining [J].

Xia, F ;

Taghian, DG ;

DeFrank, JS ;

Zeng, ZC ;

Willers, H ;

Iliakis, G ;

Powell, SN .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2001, 98 (15) :8644-8649

[120] Centrosome amplification and a defective G2-M cell cycle checkpoint induce genetic instability in BRCA1 exon 11 isoform-deficient cells [J].

Xu, XL ;

Weaver, Z ;

Linke, SP ;

Li, CL ;

Gotay, J ;

Wang, XW ;

Harris, CC ;

Ried, T ;

Deng, CX .

MOLECULAR CELL, 1999, 3 (03) :389-395

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