Tonsil-derived mesenchymal progenitor cells acquire a follicular dendritic cell phenotype under cytokine stimulation

被引：26

作者：

Cho, Kyung-Ah ^{[1
]}

Kim, Ji-Yon ^{[1
]}

Kim, Han Su ^{[2
]}

Ryu, Kyung-Ha ^{[3
]}

Woo, So-Youn ^{[1
]}

机构：

[1] Ewha Womans Univ, Sch Med, Dept Microbiol, Seoul 158710, South Korea

[2] Ewha Womans Univ, Sch Med, Dept Otorhinolaryngol, Seoul 158710, South Korea

[3] Ewha Womans Univ, Sch Med, Dept Pediat, Seoul 158710, South Korea

来源：

CYTOKINE | 2012年 / 59卷 / 02期

基金：

新加坡国家研究基金会;

关键词：

Follicular dendritic cells; Mesenchymal cells; Tonsillar stromal cells; Differentiation;

D O I：

10.1016/j.cyto.2012.04.016

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

Tonsils comprise part of the mucosal immune system and contain lymphocytes, macrophages, and follicular dendritic cells (FDCs). FDCs are located in the B cell area of the follicles of secondary lymphoid organs, such as the spleen, tonsils, or lymph nodes, and they trap and retain immune complexes on their surfaces to regulate B cell activation and maturation. Stromal cells from the palatine tonsils are often used for FDC in vitro studies, and it has been reported that human palatine tonsils may be a good source of multipotent mesenchymal cells. Therefore, we assessed whether tonsil-derived mesenchymal stromal cells could differentiate into a FDC-like phenotype. We discovered that stromal cells isolated from human tonsils not only had the potential to differentiate into various cell types of mesenchymal origin, but they also could differentiate into FDC-like cells under cytokine stimulation in vitro. (C) 2012 Elsevier Ltd. All rights reserved.

引用

页码：211 / 214

页数：4

共 9 条

[1]

CLARK EA, 1992, J IMMUNOL, V148, P3327

[2]

Human palatine tonsil: a new potential tissue source of multipotent mesenchymal progenitor cells [J].