Single-nucleotide polymorphism-based population genetic analysis of Mycobacterium tuberculosis strains from 4 geographic sites

被引：162

作者：

Gutacker, MM

Mathema, B

Soini, H

Shashkina, E

Kreiswirth, BN

Graviss, EA

Musser, JM

机构：

[1] NIAID, Lab Human Bacterial Pathogenesis, Rocky Mt Biol Labs, NIH, Hamilton, MT USA

[2] Publ Hlth Res Inst, TB Ctr, Newark, NJ USA

[3] Columbia Univ, Mailman Sch Publ Hlth, Dept Epidemiol, New York, NY 10027 USA

[4] Baylor Coll Med, Dept Pathol, Ctr Human Infect Dis Res, Houston, TX 77030 USA

[5] KTL Natl Publ Hlth Inst, Mycobacterial Reference Lab, Turku, Finland

来源：

JOURNAL OF INFECTIOUS DISEASES | 2006年 / 193卷 / 01期

关键词：

D O I：

10.1086/498574

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

We studied genetic relationships among 5069 Mycobacterium tuberculosis strains recovered from patients enrolled in 4 population-based studies in the United States and Europe, by analysis of 36 synonymous single-nucleotide polymorphisms (SNPs). All strains were assigned to 1 of 9 major genetic clusters based on sSNP profile. The same 9 genetic clusters were revealed by analysis of 227 nonsynonymous SNPs, 121 intergenic SNPs, and concatenated profiles of 578 SNPs available for a subset of 48 representative strains. IS6110 profiles, spoligotypes, and mycobacterial interspersed repetitive unit patterns were nonrandomly associated with SNP-based phylogenetic lineages, together indicating a strongly clonal population structure. Isolates of the 9 genetic clusters were not distributed with equal frequency in all localities, reflecting geographic subdivision. The SNP-based phylogenetic framework provides new insight into the worldwide evolution of M. tuberculosis and a gateway for investigating genotype-disease phenotype relationships in large samples of strains.

引用

页码：121 / 128

页数：8

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