Poriacosones A and B:: two new lanostane triterpenoids from Poria cocos

被引：75

作者：

Zheng, Yan ^{[1
]}

Yang, Xiu-Wei ^{[1
]}

机构：

[1] Peking Univ, Sch Pharmaceut Sci, State Key Lab Nat & Biomimet Drugs, Beijing 100871, Peoples R China

来源：

JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH | 2008年 / 10卷 / 07期

基金：

中国国家自然科学基金; 国家高技术研究发展计划(863计划);

关键词：

Poria cocos; lanostane triterpenoids; poriacosone A; poriacosone B;

D O I：

10.1080/10286020802133597

中图分类号：

Q94 [植物学];

学科分类号：

071001 [植物学];

摘要：

Two new lanostane triterpenoids, poriacosones A (8) and B (9), together with eight known compounds were isolated from the sclerotia of Poria cocos (Schw.) Wolf (Polyporaceae), and identified by spectroscopic analysis, including IR, UV, CD, ESI -TOF-MS, HR-SIMS, 1D-, and 2D-NMR spectra. The structures of the new compounds were established as 3 alpha, 16 alpha-dihydroxy- 24-oxolanost-7,9(11)-dien-21-oic acid (8) and 3 beta, 16 alpha-dihydroxy-24-oxolanost-7,9( 11)-dien-21-oic acid (9).

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页码：640 / 646

页数：7

相关论文

共 12 条

[1]

THE CHEMISTRY OF FUNGI .23. TUMULOSIC ACID [J].

CORT, LA ;

GASCOIGNE, RM ;

HOLKER, JSE ;

RALPH, BJ ;

ROBERTSON, A ;

SIMES, JJH .

JOURNAL OF THE CHEMICAL SOCIETY, 1954, (NOV) :3713-3721

[2]

Antimicrobial steroids from the fungus Fomitopsis pinicola [J].

Keller, AC ;

Maillard, MP ;

Hostettmann, K .

PHYTOCHEMISTRY, 1996, 41 (04) :1041-1046

[3]

Nukaya H, 1996, CHEM PHARM BULL, V44, P847, DOI 10.1248/cpb.44.847

[4]

Pharmacopoeia N., 2005, PHARM PEOPL REP CHIN, V1, P166

[5]

SHEN Q, 1999, CHIN J MED CHEM, V9, P271

[6]

Anti-emetic principles of Poria cocos [J].

Tai, T ;

Akita, Y ;

Kinoshita, K ;

Koyama, K ;

Takahashi, K ;

Watanabe, K .

PLANTA MEDICA, 1995, 61 (06) :527-530

[7]

A LANOSTANE TRITERPENOID FROM PORIA-COCOS [J].

TAI, T ;

AKAHORI, A ;

SHINGU, T .

PHYTOCHEMISTRY, 1992, 31 (07) :2548-2549

[8]

ISOLATION OF LANOSTANE-TYPE TRITERPENE ACIDS HAVING AN ACETOXYL GROUP FROM SCLEROTIA OF PORIA-COCOS [J].

TAI, T ;

SHINGU, T ;

KIKUCHI, T ;

TEZUKA, Y ;

AKAHORI, A .

PHYTOCHEMISTRY, 1995, 40 (01) :225-231

[9]

TRITERPENES FROM THE SURFACE-LAYER OF PORIA-COCOS [J].

TAI, T ;

SHINGU, T ;

KIKUCHI, T ;

TEZUKA, Y ;

AKAHORI, A .

PHYTOCHEMISTRY, 1995, 39 (05) :1165-1169

[10]

Inhibition of tumor-promoting effects by poricoic acids G and H and other lanostane-type triterpenes and cytotoxic activity of poricoic acids A and G from Poria cocos [J].

Ukiya, M ;

Akihisa, T ;

Tokuda, H ;

Hirano, M ;

Oshikubo, M ;

Nobukuni, Y ;

Kimura, Y ;

Tai, T ;

Kondo, S ;

Nishino, H .

JOURNAL OF NATURAL PRODUCTS, 2002, 65 (04) :462-465