Integrins in cell migration - the actin connection

被引：329

作者：

Vicente-Manzanares, Miguel ^{[1
]}

Choi, Colin Kiwon ^{[1
,2
]}

Horwitz, Alan Rick ^{[1
]}

机构：

[1] Univ Virginia, Sch Med, Dept Cell Biol, Charlottesville, VA 22908 USA

[2] Univ Virginia, Sch Med, Dept Biomed Engn, Charlottesville, VA 22908 USA

来源：

JOURNAL OF CELL SCIENCE | 2009年 / 122卷 / 02期

关键词：

Actin; Integrin; Migration; Adhesion; RHO-ASSOCIATED KINASE; BINDING PROTEIN RHO; FOCAL ADHESION KINASE; ALPHA-ACTININ; ARP2/3; COMPLEX; STRESS FIBERS; LEADING-EDGE; TYROSINE PHOSPHORYLATION; MEMBRANE PROTRUSION; REGULATES ADHESION;

D O I：

10.1242/jcs.018564

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The connection between integrins and actin is driving the field of cell migration in new directions. Integrins and actin are coupled through a physical linkage, which provides traction for migration. Recent studies show the importance of this linkage in regulating adhesion organization and development. Actin polymerization orchestrates adhesion assembly near the leading edge of a migrating cell, and the dynamic cross-linking of actin filaments promotes adhesion maturation. Breaking the linkage between actin and integrins leads to adhesion disassembly. Recent quantitative studies have revealed points of slippage in the linkage between actin and integrins, showing that it is not always efficient. Regulation of the assembly and organization of adhesions and their linkage to actin relies on signaling pathways that converge on components that control actin polymerization and organization.

引用

页码：199 / 206

页数：8

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