Relaxivities of human liver and spleen ferritin

被引:26
作者
Gossuin, Y [1 ]
Muller, RN
Gillis, P
Bartel, L
机构
[1] Univ Mons, Fac Med, Serv Phys Expt & Biol, Biol Phys Dept, B-7000 Mons, Belgium
[2] Univ Mons, NMR, B-7000 Mons, Belgium
[3] Univ Mons, Mol Imaging Lab, Dept Gen Organ & Biomed Chem, B-7000 Mons, Belgium
关键词
ferritin; liver; spleen; relaxation times; iron content of tissues;
D O I
10.1016/j.mri.2005.10.009
中图分类号
R8 [特种医学]; R445 [影像诊断学];
学科分类号
1002 ; 100207 ; 1009 ;
摘要
Ferritin, the iron-storing protein of mammals, is known to darken T-2-weighted magnetic resonance images. This darkening can be used to noninvasively measure an organ's iron content. Significant discrepancies exist between T-2 data obtained with ferritin-containing tissues and with aqueous solutions of horse spleen ferritin (HSF). The NMR properties of stable human ferritin have never been studied in aqueous solutions. Relaxometry results on human liver and spleen ferritin are reported here, showing that the relaxation induced in aqueous solutions by human ferritins is comparable to that induced by HSF. As a consequence, the differences between ferritin-containing human tissues and ferritin solutions cannot be attributed to different NMR properties of human and horse ferritins, but probably to a clustering of the protein in vivo. (c) 2005 Elsevier Inc. All rights reserved.
引用
收藏
页码:1001 / 1004
页数:4
相关论文
共 40 条
[1]   FIELD-DEPENDENT TRANSVERSE RELAXATION RATE INCREASE MAY BE A SPECIFIC MEASURE OF TISSUE IRON STORES [J].
BARTZOKIS, G ;
ARAVAGIRI, M ;
OLDENDORF, WH ;
MINTZ, J ;
MARDER, SR .
MAGNETIC RESONANCE IN MEDICINE, 1993, 29 (04) :459-464
[2]   MRI evaluation of brain iron in earlier- and later-onset Parkinson's disease and normal subjects [J].
Bartzokis, G ;
Cummings, JL ;
Markham, CH ;
Marmarelis, PZ ;
Treciokas, LJ ;
Tishler, TA ;
Marder, SR ;
Mintz, J .
MAGNETIC RESONANCE IMAGING, 1999, 17 (02) :213-222
[3]   Hepatic iron concentration: Noninvasive estimation by means of MR imaging techniques [J].
Bonkovsky, HL ;
Rubin, RB ;
Cable, EE ;
Davidoff, A ;
Rijcken, THP ;
Stark, DD .
RADIOLOGY, 1999, 212 (01) :227-234
[4]   Noninvasive measurement of iron: report of an NIDDK workshop [J].
Brittenham, GM ;
Badman, DG .
BLOOD, 2003, 101 (01) :15-19
[5]   COMPARISON OF T2 RELAXATION IN BLOOD, BRAIN, AND FERRITIN [J].
BROOKS, RA ;
VYMAZAL, J ;
BULTE, JWM ;
BAUMGARNER, CD ;
TRAN, V .
JMRI-JOURNAL OF MAGNETIC RESONANCE IMAGING, 1995, 5 (04) :446-450
[6]  
BROWN A, 2003, EL MICR AN C OXF
[7]   FREQUENCY-DEPENDENCE OF MR RELAXATION-TIMES .2. IRON-OXIDES [J].
BULTE, JWM ;
VYMAZAL, J ;
BROOKS, RA ;
PIERPAOLI, C ;
FRANK, JA .
JOURNAL OF MAGNETIC RESONANCE IMAGING, 1993, 3 (04) :641-648
[8]   Hepatic hemosiderosis in non-human primates: Quantification of liver iron using different field strengths [J].
Bulte, JWM ;
Miller, GF ;
Vymazal, J ;
Brooks, RA ;
Frank, JA .
MAGNETIC RESONANCE IN MEDICINE, 1997, 37 (04) :530-536
[9]   Proton transverse relaxation rate (R2) images of iron-loaded liver tissuepping local tissue iron concentrations with MRI [J].
Clark, PR ;
Chua-anusorn, W ;
St Pierre, TG .
MAGNETIC RESONANCE IN MEDICINE, 2003, 49 (03) :572-575
[10]  
Cornell R.M., 1996, IRON OXIDES STRUCTUR, P573