Highly diastereo- and enantioselective copper-catalyzed domino reduction/aldol reaction of ketones with methyl acrylate

被引：141

作者：

Deschamp, J ^{[1
]}

Chuzel, O ^{[1
]}

Hannedouche, J ^{[1
]}

Riant, O ^{[1
]}

机构：

[1] Catholic Univ Louvain, Unite Chim Organ & Med, B-1348 Louvain, Belgium

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2006年 / 45卷 / 08期

关键词：

aldol reaction; copper; enantioselectivity; enolates; hydrosilylation;

D O I：

10.1002/anie.200503791

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

(Chemical Equation Presented) A good choice: A new catalytic method was found for the construction of stereogenic quaternary carbon centers through a copper-catalyzed domino conjugated reduction/aldol reaction of methyl acrylate with various alkyl aryl ketones. The proper choice of the chiral diphosphine ligand leads to high chemo-, diastereo-, and enantioselectivity. © 2006 Wiley-VCH Verlag GmbH & Co. KGaA.

引用

页码：1292 / 1297

页数：6

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