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Advances in Rho-dependent actin regulation and oncogenic transformation

被引：76
作者：
Frame, MC
Brunton, VG
机构：
[1] Univ Glasgow, Canc Res Campaign Beatson Labs, Beatson Inst Canc Res, Glasgow G61 1BD, Lanark, Scotland
[2] Univ Glasgow, Canc Res Campaign Beatson Labs, Inst Biomed & Life Sci, Glasgow G61 1BD, Lanark, Scotland
来源：
CURRENT OPINION IN GENETICS & DEVELOPMENT | 2002年 / 12卷 / 01期
关键词：
D O I：
10.1016/S0959-437X(01)00261-1
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Cellular movement is central to invasion. The Rho family of small GTPases co-ordinate the cytoskeletal and adhesion modelling within cells that is crucial for normal migratory responses. Consequently, Rho proteins, and their regulators and effectors, are targets for subversion during oncogenic transformation and tumour development. Recent findings have thrown light on how actin regulators may be linked to oncogenesis and the development of cancer.
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收藏
页码：36 / 43
页数：8
相关论文
共 91 条
  • [31] P60(V-SRC) CAUSES TYROSINE PHOSPHORYLATION AND INACTIVATION OF THE N-CADHERIN CATENIN CELL-ADHESION SYSTEM
    HAMAGUCHI, M
    MATSUYOSHI, N
    OHNISHI, Y
    GOTOH, B
    TAKEICHI, M
    NAGAI, Y
    [J]. EMBO JOURNAL, 1993, 12 (01) : 307 - 314
  • [32] Inhibition of invasion of epithelial cells by Tiam1-Rac signaling
    Hordijk, PL
    tenKlooster, JP
    vanderKammen, RA
    Michiels, F
    Oomen, LCJM
    Collard, JG
    [J]. SCIENCE, 1997, 278 (5342) : 1464 - 1466
  • [33] EMS1 amplification can occur independently of CCND1 or INT-2 amplification at 11q13 and may identify different phenotypes in primary breast cancer
    Hui, R
    Campbell, DH
    Lee, CSL
    McCaul, K
    Horsfall, DJ
    Musgrove, EA
    Daly, RJ
    Seshadri, R
    Sutherland, RL
    [J]. ONCOGENE, 1997, 15 (13) : 1617 - 1623
  • [34] Ishizaki T, 2001, NAT CELL BIOL, V3, P8
  • [35] An essential part for Rho-associated kinase in the transcellular invasion of tumor cells
    Itoh, K
    Yoshioka, K
    Akedo, H
    Uehata, M
    Ishizaki, T
    Narumiya, S
    [J]. NATURE MEDICINE, 1999, 5 (02) : 221 - 225
  • [36] Abnormal expression and function of the E-cadherin-catenin complex in gastric carcinoma cell lines
    Jawhari, AU
    Noda, M
    Farthing, MJG
    Pignatelli, M
    [J]. BRITISH JOURNAL OF CANCER, 1999, 80 (3-4) : 322 - 330
  • [37] The cell-polarity protein Par6 links Par3 and atypical protein kinase C to Cdc42
    Joberty, G
    Petersen, C
    Gao, L
    Macara, IG
    [J]. NATURE CELL BIOLOGY, 2000, 2 (08) : 531 - 539
  • [38] Effects of regulated expression of mutant RhoA and Rac1 small GTPases on the development of epithelial (MDCK) cell polarity
    Jou, TS
    Nelson, WJ
    [J]. JOURNAL OF CELL BIOLOGY, 1998, 142 (01) : 85 - 100
  • [39] Regulation of the cytoskeleton and cell adhesion by the Rho family GTPases in mammalian cells
    Kaibuchi, K
    Kuroda, S
    Amano, M
    [J]. ANNUAL REVIEW OF BIOCHEMISTRY, 1999, 68 : 459 - 486
  • [40] Integrins and GTPases in tumour cell growth, motility and invasion
    Keely, P
    Parise, L
    Juliano, R
    [J]. TRENDS IN CELL BIOLOGY, 1998, 8 (03) : 101 - 106
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