The expression of Sox17 identifies and regulates haemogenic endothelium

被引：126

作者：

Clarke, Raedun L. ^{[1
]}

Yzaguirre, Amanda D. ^{[2
]}

Yashiro-Ohtani, Yumi ^{[2
]}

Bondue, Antoine ^{[3
]}

Blanpain, Cedric ^{[3
]}

Pear, Warren S. ^{[2
]}

Speck, Nancy A. ^{[2
]}

Keller, Gordon ^{[1
]}

机构：

[1] Univ Hlth Network, McEwen Ctr Regenerat Med, Toronto, ON M5G 1L7, Canada

[2] Univ Penn, Abramson Family Canc Res Inst, Philadelphia, PA 19104 USA

[3] Univ Libre Brussels, IRIBHM, B-1070 Brussels, Belgium

来源：

NATURE CELL BIOLOGY | 2013年 / 15卷 / 05期

基金：

美国国家卫生研究院; 加拿大健康研究院;

关键词：

HEMATOPOIETIC STEM-CELLS; AORTIC ENDOTHELIUM; YOLK-SAC; MOUSE EMBRYOS; AGM REGION; PROGENITORS; GENERATION; SPECIFICATION; TRANSITION; ONSET;

D O I：

10.1038/ncb2724

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Although it is well recognized that haematopoietic stem cells (HSCs) develop from a specialized population of endothelial cells known as haemogenic endothelium, the regulatory pathways that control this transition are not well defined. Here we identify Sox17 as a key regulator of haemogenic endothelial development. Analysis of Sox17-GFP reporter mice revealed that Sox17 is expressed in haemogenic endothelium and emerging HSCs and that it is required for HSC development. Using the mouse embryonic stem cell differentiation model, we show that Sox17 is also expressed in haemogenic endothelium generated in vitro and that it plays a pivotal role in the development and/or expansion of haemogenic endothelium through the Notch signalling pathway. Taken together, these findings position Sox17 as a key regulator of haemogenic endothelial and haematopoietic development.

引用

页码：502 / +

页数：15

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