Double functionalisation of carbon nanotubes for multimodal drug delivery

被引:314
作者
Pastorin, G
Wu, W
Wieckowski, S
Briand, JP
Kostarelos, K
Prato, M [1 ]
Bianco, A
机构
[1] Univ Trieste, Dipartimento Sci Farmaceut, I-34127 Trieste, Italy
[2] CNRS, UPR9021, Inst Biol Mol & Cellulaire, F-67084 Strasbourg, France
[3] Univ London, Sch Pharm, Ctr Drug Delivery Res, London WC1N 1AX, England
关键词
D O I
10.1039/b516309a
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
Multi-walled carbon nanotubes have been covalently functionalised via 1,3-dipolar cycloaddition of azomethine ylides with orthogonally protected amino functions that can be selectively deprotected and subsequently modified with drugs and fluorescent probes.
引用
收藏
页码:1182 / 1184
页数:3
相关论文
共 28 条
[11]  
2-N
[12]   Nanotube molecular transporters: Internalization of carbon nanotube-protein conjugates into mammalian cells [J].
Kam, NWS ;
Jessop, TC ;
Wender, PA ;
Dai, HJ .
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2004, 126 (22) :6850-6851
[13]   Carbon nanotubes as intracellular protein transporters: Generality and biological functionality [J].
Kam, NWS ;
Dai, HJ .
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2005, 127 (16) :6021-6026
[14]   Functionalization of carbon nanotubes via cleavable disulfide bonds for efficient intracellular delivery of siRNA and potent gene silencing [J].
Kam, NWS ;
Liu, Z ;
Dai, HJ .
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2005, 127 (36) :12492-12493
[15]   Carbon nanotubes as multifunctional biological transporters and near-infrared agents for selective cancer cell destruction [J].
Kam, NWS ;
O'Connell, M ;
Wisdom, JA ;
Dai, HJ .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2005, 102 (33) :11600-11605
[16]   Carbon nanotube-mediated delivery of peptides and genes to cells: translating nanobiotechnology to therapeutics [J].
Kostarelos, K ;
Lacerda, L ;
Partidos, CD ;
Prato, M ;
Blanco, A .
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY, 2005, 15 (01) :41-47
[17]   Advances toward bioapplications of carbon nanotubes [J].
Lin, Y ;
Taylor, S ;
Li, HP ;
Fernando, KAS ;
Qu, LW ;
Wang, W ;
Gu, LR ;
Zhou, B ;
Sun, YP .
JOURNAL OF MATERIALS CHEMISTRY, 2004, 14 (04) :527-541
[18]   The emerging field of nanotube biotechnology [J].
Martin, CR ;
Kohli, P .
NATURE REVIEWS DRUG DISCOVERY, 2003, 2 (01) :29-37
[19]   SELECTIVE COUPLING OF METHOTREXATE TO PEPTIDE-HORMONE CARRIERS THROUGH A GAMMA-CARBOXAMIDE LINKAGE OF ITS GLUTAMIC-ACID MOIETY - BENZOTRIAZOL-1-YLOXYTRIS(DIMETHYLAMINO)PHOSPHONIUM HEXAFLUOROPHOSPHATE ACTIVATION IN SALT COUPLING [J].
NAGY, A ;
SZOKE, B ;
SCHALLY, AV .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1993, 90 (13) :6373-6376
[20]   Immunization with peptide-functionalized carbon nanotubes enhances virus-specific neutralizing antibody responses [J].
Pantarotto, D ;
Partidos, CD ;
Hoebeke, J ;
Brown, F ;
Kramer, E ;
Briand, JP ;
Muller, S ;
Prato, M ;
Bianco, A .
CHEMISTRY & BIOLOGY, 2003, 10 (10) :961-966