The Composition, Functions, and Regulation of the Budding Yeast Kinetochore

被引：136

作者：

Biggins, Sue ^{[1
]}

机构：

[1] Fred Hutchinson Canc Res Ctr, Div Basic Sci, Seattle, WA 98109 USA

来源：

GENETICS | 2013年 / 194卷 / 04期

基金：

美国国家卫生研究院;

关键词：

SPINDLE-ASSEMBLY CHECKPOINT; SACCHAROMYCES-CEREVISIAE KINETOCHORE; HISTONE H3 VARIANT; ANAPHASE-PROMOTING COMPLEX; SISTER-CHROMATID COHESION; CHROMOSOME BI-ORIENTATION; UBIQUITIN-DEPENDENT DEGRADATION; MICROTUBULE-ATTACHMENT SITES; CENTROMERE-BINDING PROTEIN; CELL-CYCLE PROGRESSION;

D O I：

10.1534/genetics.112.145276

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

The propagation of all organisms depends on the accurate and orderly segregation of chromosomes in mitosis and meiosis. Budding yeast has long served as an outstanding model organism to identify the components and underlying mechanisms that regulate chromosome segregation. This review focuses on the kinetochore, the macromolecular protein complex that assembles on centromeric chromatin and maintains persistent load-bearing attachments to the dynamic tips of spindle microtubules. The kinetochore also serves as a regulatory hub for the spindle checkpoint, ensuring that cell cycle progression is coupled to the achievement of proper microtubule-kinetochore attachments. Progress in understanding the composition and overall architecture of the kinetochore, as well as its properties in making and regulating microtubule attachments and the spindle checkpoint, is discussed.

引用

页码：817 / 846

页数：30

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