Identification and characterization of a negative regulator of FtsZ ring formation in Bacillus subtilis

被引：181

作者：

Levin, PA ^{[1
]}

Kurtser, IG ^{[1
]}

Grossman, AD ^{[1
]}

机构：

[1] MIT, Dept Biol, Cambridge, MA 02139 USA

来源：

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 1999年 / 96卷 / 17期

关键词：

D O I：

10.1073/pnas.96.17.9642

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

During the bacterial cell cycle, the tubulin-like cell-division protein FtsZ polymerizes into a ring structure that establishes the location of the nascent division site. We have identified a regulator of FtsZ ring formation in Bacillus subtilis, This protein, EzrA, modulates the frequency and position of FtsZ ring formation. The loss of ezrA resulted in cells with multiple FtsZ rings located at polar as well as medial sites. Moreover, the critical concentration of FtsZ required for ring formation was lower in ezrA null mutants than in wild-type cells. EzrA was associated with the cell membrane and also colocalized with FtsZ to the nascent septal site. We propose that EzrA interacts either with FtsZ or with one of its binding partners to promote depolymerization.

引用

页码：9642 / 9647

页数：6

共 39 条

[1] FTSZ IN BACILLUS-SUBTILIS IS REQUIRED FOR VEGETATIVE SEPTATION AND FOR ASYMMETRIC SEPTATION DURING SPORULATION [J].