Induction of differentiation of pre-NKT cells to mature Vα14 NKT cells by granulocyte macrophage colony-stimulating factor

被引:47
作者
Sato, H
Nakayama, T
Tanaka, Y
Yamashita, Y
Saito, Y
Taniguchi, M
机构
[1] Chiba Univ, CREST, Chiba 2608670, Japan
[2] Chiba Univ, Dept Mol Immunol, Grad Sch Med, Chiba 2608670, Japan
[3] Chiba Univ, Sch Med, Dept Dev Immunol, Chiba 2608670, Japan
[4] Chiba Univ, Sch Med, Dept Internal Med 2, Chiba 2608670, Japan
关键词
D O I
10.1073/pnas.96.13.7439
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
V alpha 14 NKT cells express an invariant antigen receptor encoded by Va14 and J alpha 281 gene segments as well as natural killer (NK) markers, including NK1.1. Here, we describe a precursor population of NKT cells (pre-NKT) that expresses NK1.1, T cell antigen receptor beta, pT alpha, and RAG1/2 but not V alpha 14 and surface CD3 epsilon. Such pre-NKT cells were differentiated successfully in vitro into mature CD3 epsilon(+) V alpha 14(+) NKT tells by IL-15 and granulocyte/macrophage colony-stimulating factor (GR;I-CSF) in conjunction with stroma cells. Interestingly, only GM-CSF without stroma cells induced the V alpha 14-J alpha 281 gene rearrangement in the pre-NKT cells. This also was confirmed by the findings that the number of mature V alpha 14 NKT cells and the frequency of V alpha 14-J alpha 281 rearrangements were decreased significantly in the mice lacking a GM-CSF receptor component, common beta-chain. These results suggest a crucial role of GM-CSF in the development of V alpha 14 NKT cells in vivo.
引用
收藏
页码:7439 / 7444
页数:6
相关论文
共 28 条
[11]   CLONING AND EXPRESSION OF A GENE ENCODING AN INTERLEUKIN-3 RECEPTOR-LIKE PROTEIN - IDENTIFICATION OF ANOTHER MEMBER OF THE CYTOKINE RECEPTOR GENE FAMILY [J].
GORMAN, DM ;
ITOH, N ;
KITAMURA, T ;
SCHREURS, J ;
YONEHARA, S ;
YAHARA, I ;
ARAI, KI ;
MIYAJIMA, A .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1990, 87 (14) :5459-5463
[12]   CD1d-restricted and TCR-mediated activation of V(alpha)14 NKT cells by glycosylceramides [J].
Kawano, T ;
Cui, JQ ;
Koezuka, Y ;
Toura, I ;
Kaneko, Y ;
Motoki, K ;
Ueno, H ;
Nakagawa, R ;
Sato, H ;
Kondo, E ;
Koseki, H ;
Taniguchi, M .
SCIENCE, 1997, 278 (5343) :1626-1629
[13]   AN INVARIANT T-CELL RECEPTOR-ALPHA CHAIN IS USED BY A UNIQUE SUBSET OF MAJOR HISTOCOMPATIBILITY COMPLEX CLASS I-SPECIFIC CD4+ AND CD4-8- T-CELLS IN MICE AND HUMANS [J].
LANTZ, O ;
BENDELAC, A .
JOURNAL OF EXPERIMENTAL MEDICINE, 1994, 180 (03) :1097-1106
[14]   IL-15 receptor maintains lymphoid homeostasis by supporting lymphocyte homing and proliferation [J].
Lodolce, JP ;
Boone, DL ;
Chai, S ;
Swain, RE ;
Dassopoulos, T ;
Trettin, S ;
Ma, A .
IMMUNITY, 1998, 9 (05) :669-676
[15]   EXTRATHYMIC DEVELOPMENT OF V-ALPHA-14-POSITIVE T-CELLS [J].
MAKINO, Y ;
YAMAGATA, N ;
SASHO, T ;
ADACHI, Y ;
KANNO, R ;
KOSEKI, H ;
KANNO, M ;
TANIGUCHI, M .
JOURNAL OF EXPERIMENTAL MEDICINE, 1993, 177 (05) :1399-1408
[16]   Development of V alpha 14(+) NK T cells in the early stages of embryogenesis [J].
Makino, Y ;
Kanno, R ;
Koseki, H ;
Taniguchi, M .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1996, 93 (13) :6516-6520
[17]   CD1d1 mutant mice are deficient in natural T cells that promptly produce IL-4 [J].
Mendiratta, SK ;
Martin, WD ;
Hong, S ;
Boesteanu, A ;
Joyce, S ;
VanKaer, L .
IMMUNITY, 1997, 6 (04) :469-477
[18]   RAG-1-DEFICIENT MICE HAVE NO MATURE LYMPHOCYTES-B AND LYMPHOCYTES-T [J].
MOMBAERTS, P ;
IACOMINI, J ;
JOHNSON, RS ;
HERRUP, K ;
TONEGAWA, S ;
PAPAIOANNOU, VE .
CELL, 1992, 68 (05) :869-877
[19]   Hematopoiesis in mice lacking the entire granulocyte-macrophage colony-stimulating factor/interleukin-3/interleukin-5 functions [J].
Nishinakamura, R ;
Miyajima, A ;
Mee, PJ ;
Tybulewicz, VLJ ;
Murray, R .
BLOOD, 1996, 88 (07) :2458-2464
[20]   MICE DEFICIENT FOR THE IL-3/GM-CSF/IL-5 BETA-C RECEPTOR EXHIBIT LUNG PATHOLOGY AND IMPAIRED IMMUNE-RESPONSE, WHILE BETA-IL3 RECEPTOR-DEFICIENT MICE ARE NORMAL [J].
NISHINAKAMURA, R ;
NAKAYAMA, N ;
HIRABAYASHI, Y ;
INOUE, T ;
AUD, D ;
MCNEIL, T ;
AZUMA, S ;
YOSHIDA, S ;
TOYODA, Y ;
ARAI, K ;
MIYAJIMA, A ;
MURRAY, R .
IMMUNITY, 1995, 2 (03) :211-222